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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
11
hits in this display
Target
Cathepsin K
(Homo sapiens (Human))
Gsk
Ligand
BDBM19778
((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
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Affinity Data
Ki: 0.0410nM ΔG°: -58.7kJ/mole
pH: 5.5 T: 2°C
Assay Description:
Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Target
Cathepsin L2
(Homo sapiens (Human))
Gsk
Ligand
BDBM19778
((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
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Affinity Data
Ki: 0.0630nM
Assay Description:
Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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Target
Procathepsin L
(Homo sapiens (Human))
Gsk
Ligand
BDBM19778
((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
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Affinity Data
Ki: 0.0680nM ΔG°: -57.4kJ/mole
pH: 5.5 T: 2°C
Assay Description:
Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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Article
PubMed
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Target
Cathepsin S
(Homo sapiens (Human))
Gsk
Ligand
BDBM19778
((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
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Affinity Data
Ki: 1.60nM
Assay Description:
Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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Article
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Target
Cathepsin K
(Rattus norvegicus)
Gsk
Ligand
BDBM19778
((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
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Affinity Data
Ki: 8nM
Assay Description:
Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Cathepsin B
(Homo sapiens (Human))
Gsk
Ligand
BDBM19778
((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
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Affinity Data
Ki: 13nM
Assay Description:
Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Cathepsin K
(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM19778
((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
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Affinity Data
IC50: 0.5nM
Assay Description:
Inhibition of rabbit cathepsin K
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
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B.MOAD
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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Article
PubMed
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Target
Cathepsin K
(Homo sapiens (Human))
Gsk
Ligand
BDBM19778
((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
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Copy InChI
Affinity Data
IC50: 0.5nM
Assay Description:
Inhibition of humanized rabbit cathepsin K
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Procathepsin L
(Homo sapiens (Human))
Gsk
Ligand
BDBM19778
((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
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Affinity Data
IC50: 2nM
Assay Description:
Inhibition of cathepsin L in human HepG2 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Cathepsin S
(Homo sapiens (Human))
Gsk
Ligand
BDBM19778
((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
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Affinity Data
IC50: 8nM
Assay Description:
Inhibition of cathepsin S in human ramos cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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PubMed
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Target
Cathepsin B
(Homo sapiens (Human))
Gsk
Ligand
BDBM19778
((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
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Affinity Data
IC50: 14nM
Assay Description:
Inhibition of cathepsin B in human HepG2 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI