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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University

Curated by ChEMBL
LigandPNGBDBM50462328(CHEMBL4251469)
Affinity DataIC50:  50nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Gazi University

Curated by ChEMBL
LigandPNGBDBM50462328(CHEMBL4251469)
Affinity DataIC50:  420nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomal fractions assessed as reduction in PGE2 production preincubated for 15 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Gazi University

Curated by ChEMBL
LigandPNGBDBM50462328(CHEMBL4251469)
Affinity DataIC50:  600nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 incubated for 15 mins prior to prewarming for 30 secs followed by CaCl2+ and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Gazi University

Curated by ChEMBL
LigandPNGBDBM50462328(CHEMBL4251469)
Affinity DataIC50:  6.19E+3nMAssay Description:Inhibition of human LTC4 synthase expressed in HEK293 cell microsomes preincubated for 10 mins followed by LTA4-methyl ester addition and measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed