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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))TBA
LigandPNGBDBM50385390(CHEMBL2036163)
Affinity DataIC50:  40nMAssay Description:Inhibition of FLAP in human monocyte assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated with enzyme for 15 mins fol...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))TBA
LigandPNGBDBM50385390(CHEMBL2036163)
Affinity DataIC50:  150nMAssay Description:Inhibition of FLAP in human neutrophil assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation using arachidonic acid as substrate pr...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50385390(CHEMBL2036163)
Affinity DataIC50:  200nMAssay Description:Inhibition of mPGES-1 activity in IL-1beta human A549 microsome using PGH2 as substrate preincubated for 15 mins followed by substrate addition for 1...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))TBA
LigandPNGBDBM50385390(CHEMBL2036163)
Affinity DataIC50:  310nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))TBA
LigandPNGBDBM50385390(CHEMBL2036163)
Affinity DataIC50:  310nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as reduction in 5-LO product formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))TBA
LigandPNGBDBM50385390(CHEMBL2036163)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated with enzyme for 15 mins ...More data for this Ligand-Target Pair
In DepthDetails PubMed