Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetHistone deacetylase (HDAC1 and HDAC2)(Homo sapiens (Human))
Shandong University

Curated by ChEMBL

LigandBDBM50148042(CHEMBL3763573)Copy SMILESCopy InChI

Affinity DataIC50:  27nMAssay Description:Inhibition of HDAC1/2 in human HeLa cell nuclear extract using color de Lys as substrate preincubated for 5 mins followed by substrate addition measu...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
DrugBankantibodypediaantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetHistone deacetylase 2(Homo sapiens (Human))
Shandong University

Curated by ChEMBL

LigandBDBM50148042(CHEMBL3763573)Copy SMILESCopy InChI

Affinity DataIC50:  165nMAssay Description:Inhibition of C-terminal GST-tagged human recombinant HDAC2 expressed in Sf9 cells after 30 mins by microtiter plate reader analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetHistone deacetylase 8(Homo sapiens (Human))
Shandong University

Curated by ChEMBL

LigandBDBM50148042(CHEMBL3763573)Copy SMILESCopy InChI

Affinity DataIC50:  2.01E+3nMAssay Description:Inhibition of C-terminal His-tagged human recombinant HDAC8 expressed in Sf9 cells after 30 mins by microtiter plate reader analysisMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI