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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525768(US11174252, Compound 455)
Affinity DataIC50:  1.5nMAssay Description:FMS: IC50 values of compounds against FMS kinase were determined by LanthaScreen™ Eu Kinase Binding Assay at Invitrogen (Life Technologies Grand...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525768(US11174252, Compound 455)
Affinity DataIC50:  3nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Nuvation Bio

US Patent
LigandPNGBDBM525768(US11174252, Compound 455)
Affinity DataIC50:  4.5nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM525768(US11174252, Compound 455)
Affinity DataIC50:  1.31E+4nMAssay Description:PI3Kδ: Briefly, this assay was conducted in buffer (Tris-HCl 40 mM (pH7.5), Orthovanadate 3 mM, MgCl2 20 mM, DTT 2 mM, CHAPS 0.05%, DMSO 1%). PI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent