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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Macrophage colony-stimulating factor 1 receptor
(Homo sapiens (Human))
Nuvation Bio
US Patent
Ligand
BDBM525768
(US11174252, Compound 455)
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Affinity Data
IC50: 1.5nM
Assay Description:
FMS: IC50 values of compounds against FMS kinase were determined by LanthaScreen Eu Kinase Binding Assay at Invitrogen (Life Technologies Grand...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Cyclin-dependent kinase 6
(Homo sapiens (Human))
Nuvation Bio
US Patent
Ligand
BDBM525768
(US11174252, Compound 455)
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Affinity Data
IC50: 3nM
Assay Description:
CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cyclin-dependent kinase 4
(Homo sapiens (Human))
Nuvation Bio
US Patent
Ligand
BDBM525768
(US11174252, Compound 455)
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Affinity Data
IC50: 4.5nM
Assay Description:
CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human))
Nuvation Bio
US Patent
Ligand
BDBM525768
(US11174252, Compound 455)
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Affinity Data
IC50: 1.31E+4nM
Assay Description:
PI3Kδ: Briefly, this assay was conducted in buffer (Tris-HCl 40 mM (pH7.5), Orthovanadate 3 mM, MgCl2 20 mM, DTT 2 mM, CHAPS 0.05%, DMSO 1%). PI...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI