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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
22
hits in this display
Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
Ki: 17nM
Assay Description:
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
Ki: 50nM
Assay Description:
Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand.
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
Ki: 55nM
Assay Description:
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
Ki: 115nM
Assay Description:
Evaluated for the binding affinity to hippocampus striatal membranes at 5-hydroxytryptamine 1A receptor binding site by using [3H]-8-OH- DPAT as a ra...
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Target
5-hydroxytryptamine receptor 1A/1B/1D/1F
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
Ki: 300nM
Assay Description:
Evaluated for binding affinity towards rat cortical membranes at 5-hydroxytryptamine 1 receptor binding site by using [3H]-5-HT as a radioligand.
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
Ki: 1.40E+3nM
Assay Description:
Evaluated for the binding affinity to porcine choroid plexus at 5-hydroxytryptamine 2C receptor binding site by using [3H]-MES as a radioligand.
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
Ki: 3.50E+3nM
Assay Description:
Binding affinity to 5-hydroxytryptamine 2 receptor in rat frontal cortical membranes by [3H]- KET displacement.
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Target
5-hydroxytryptamine receptor 1B
(Homo sapiens (Human))
Medical College Of Virginia/Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
Ki: 4.10E+3nM
Assay Description:
Agonist activity to the human recombinant 5-hydroxytryptamine 1B receptor
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
Ki: 5.90E+3nM
Assay Description:
Binding affinity to rat cortical membranes at 5-hydroxytryptamine 2 (5-HT2) receptor using [3H]KET as a radioligand
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
University Of Montana
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
Ki: 8.10E+3nM
Assay Description:
Displacement of [3H]ketanserin from rat 5HT2A receptor expressed in mouse NIH3T3 cells
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
Ki: 1.70E+5nM
Assay Description:
Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...
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Target
Cytochrome P450 2D26
(Rattus norvegicus)
Vrije Universiteit
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
IC50: 350nM
Assay Description:
Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiae
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Vrije Universiteit
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell line
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Target
Sodium/bile acid cotransporter
(Homo sapiens (Human))
Vanderbilt University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
IC50: 6.10E+3nM
Assay Description:
TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells
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Target
Sodium channel protein type 1/2/3 subunit alpha
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
IC50: 1.30E+4nM
Assay Description:
Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...
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Target
Cytochrome P450 2D4
(Rattus norvegicus)
Vrije Universiteit
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
IC50: 1.33E+5nM
Assay Description:
Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D4 expressed in Saccharomyces cerevisiae
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Target
Cytochrome P450 2D3
(Rattus norvegicus)
Vrije Universiteit
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
IC50: 1.72E+5nM
Assay Description:
Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D3 expressed in Saccharomyces cerevisiae
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Target
Cytochrome P450 2D1
(Rattus norvegicus)
Vrije Universiteit
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
IC50: 5.71E+5nM
Assay Description:
Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D1 expressed in Saccharomyces cerevisiae
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
IC50: 5.74E+5nM
Assay Description:
Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity model
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Target
Nuclear receptor subfamily 2 group E member 1
(Homo sapiens)
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
EC50: 7.20E+4nM
Assay Description:
Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
Tom'S Of Maine
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
EC50: 1.80nM
Assay Description:
Displacement of [125I]cyanopindolol from human recombinant adrenergic beta-1 receptor expressed in Rex16 cells
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Target
Beta-1/Beta-2/Beta-3 adrenergic receptor
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50246936
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
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Affinity Data
Kd: 0.700nM
Assay Description:
Binding affinity against Beta adrenergic receptor in C6-2B astrocytoma cells, using [125I]-iodohydroxybenzylpindolol-benzylpindolol([125I]-HYP)
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