Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 22 hits in this display   

TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281061((S)-(3-Isopropyl-1H-pyrazol-5-yl)(3-(6-methyl-4-(1...)
Affinity DataIC50:  0.170nMpH: 7.0 T: 2°CAssay Description:Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50:  0.340nMpH: 7.0 T: 2°CAssay Description:Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281062(US10022354, Example 2)
Affinity DataIC50:  0.840nMpH: 7.0 T: 2°CAssay Description:Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5C(Homo sapiens (Human))TBA
LigandPNGBDBM281062(US10022354, Example 2)
Affinity DataIC50:  25nMAssay Description:Inhibition of KDM5C (unknown origin ) by Alphascreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281062(US10022354, Example 2)
Affinity DataIC50:  160nMAssay Description:Inhibition of KDM5A (unknown origin ) by Alphascreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281062(US10022354, Example 2)
Affinity DataIC50:  160nMAssay Description:Inhibition of KDM5A (unknown origin ) demethylase activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50:  260nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50:  260nMAssay Description:Inhibition of KDM5A (unknown origin ) demethylase activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50:  260nMAssay Description:Inhibition of KDM5A (unknown origin ) by Alphascreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50:  260nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281061((S)-(3-Isopropyl-1H-pyrazol-5-yl)(3-(6-methyl-4-(1...)
Affinity DataIC50:  770nMAssay Description:Inhibition of KDM5A (unknown origin ) demethylase activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281061((S)-(3-Isopropyl-1H-pyrazol-5-yl)(3-(6-methyl-4-(1...)
Affinity DataIC50:  770nMAssay Description:Inhibition of KDM5A (unknown origin ) by Alphascreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50:  770nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM4C expressed in baculovirus infected Sf9 insect cells using H3K9me3 peptide as substrate af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50:  1.33E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM4C expressed in baculovirus infected Sf9 insect cells using H3K9me3 peptide as substrate af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3B(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM3B expressed in baculovirus infected Sf9 insect cells using H3K9me1 peptide as substrate af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2B(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM2B expressed in baculovirus infected Sf9 insect cells using H3K36me2 peptide as substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of KDM1A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 6A(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM6A expressed in baculovirus infected Sf9 insect cells using H3K27me3 peptide as substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone lysine demethylase PHF8(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM7B expressed in baculovirus infected Sf9 insect cells using H3K9me1 peptide as substrate af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed