Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 22 hits in this display
BDBM281061((S)-(3-Isopropyl-1H-pyrazol-5-yl)(3-(6-methyl-4-(1...)
BDBM281138(US10022354, Example 78)
IC50: 0.340nMpH: 7.0 T: 2°CAssay Description:Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...More data for this Ligand-Target Pair
BDBM281062(US10022354, Example 2)
IC50: 0.840nMpH: 7.0 T: 2°CAssay Description:Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...More data for this Ligand-Target Pair
BDBM281062(US10022354, Example 2)
BDBM281062(US10022354, Example 2)
BDBM281062(US10022354, Example 2)
BDBM281138(US10022354, Example 78)
BDBM281138(US10022354, Example 78)
BDBM281138(US10022354, Example 78)
BDBM281138(US10022354, Example 78)
IC50: 260nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
BDBM281061((S)-(3-Isopropyl-1H-pyrazol-5-yl)(3-(6-methyl-4-(1...)
BDBM281061((S)-(3-Isopropyl-1H-pyrazol-5-yl)(3-(6-methyl-4-(1...)
BDBM281138(US10022354, Example 78)
BDBM281138(US10022354, Example 78)
IC50: 1.33E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM4C expressed in baculovirus infected Sf9 insect cells using H3K9me3 peptide as substrate af...More data for this Ligand-Target Pair
BDBM281138(US10022354, Example 78)
IC50: >2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
BDBM281138(US10022354, Example 78)
BDBM281138(US10022354, Example 78)
BDBM281138(US10022354, Example 78)
BDBM281138(US10022354, Example 78)
BDBM281138(US10022354, Example 78)
BDBM281138(US10022354, Example 78)
IC50: >3.00E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5A expressed in baculovirus infected Sf9 insect cells using H3K4me3 peptide as substrate af...More data for this Ligand-Target Pair
BDBM281138(US10022354, Example 78)
EC50: >3.00E+4nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 level after 5 days by mass-spectrometric methodMore data for this Ligand-Target Pair