SMILES String Search

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 24 hits in this display

Coagulation factor XI(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542738(CHEMBL4637027)

IC50: 0.400nMAssay Description:Inhibition of human F11a using D-Leu-Pro-Arg*Rh110-D-Pro as substrate preincubated for 60 mins followed by substrate addition and measured after 60 m...More data for this Ligand-Target Pair

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3D Structure (crystal)

Coagulation factor XI(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542741(CHEMBL4647950)

IC50: <0.700nMAssay Description:Inhibition of human F11a using D-Leu-Pro-Arg*Rh110-D-Pro as substrate preincubated for 60 mins followed by substrate addition and measured after 60 m...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Plasma kallikrein(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542738(CHEMBL4637027)

IC50: 1nMAssay Description:Inhibition of PKL (unknown origin) using D-Leu-Pro-Arg*Rh110-D-Pro as substrate preincubated for 60 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair

PDB Reactome pathway
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Coagulation factor XI(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542738(CHEMBL4637027)

IC50: 10nMAssay Description:Inhibition of N-terminal human plasma F11a catalytic domain expressed in Escherichia coli strain BL21(DE3) using D-Leu-Pro-Arg*Rh110-D-Pro as substra...More data for this Ligand-Target Pair

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3D Structure (crystal)

Plasma kallikrein(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542741(CHEMBL4647950)

IC50: 16nMAssay Description:Inhibition of PKL (unknown origin) using D-Leu-Pro-Arg*Rh110-D-Pro as substrate preincubated for 60 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Coagulation factor XI(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542741(CHEMBL4647950)

IC50: 45nMAssay Description:Inhibition of N-terminal human plasma F11a catalytic domain expressed in Escherichia coli strain BL21(DE3) using D-Leu-Pro-Arg*Rh110-D-Pro as substra...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Urokinase-type plasminogen activator(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542738(CHEMBL4637027)

IC50: 170nMAssay Description:Inhibition of human uPA using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

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Tissue-type plasminogen activator(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542738(CHEMBL4637027)

IC50: 250nMAssay Description:Inhibition of human tPa using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Coagulation factor X(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542738(CHEMBL4637027)

IC50: 1.05E+3nMAssay Description:Inhibition of human F10a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Urokinase-type plasminogen activator(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542741(CHEMBL4647950)

IC50: 1.42E+3nMAssay Description:Inhibition of human uPA using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Plasminogen(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542738(CHEMBL4637027)

IC50: 1.89E+3nMAssay Description:Inhibition of human plasmin using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Coagulation factor IX(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542738(CHEMBL4637027)

IC50: 1.92E+3nMAssay Description:Inhibition of human F9a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542738(CHEMBL4637027)

IC50: 2.40E+3nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair

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Prothrombin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542738(CHEMBL4637027)

IC50: 2.57E+3nMAssay Description:Inhibition of human thrombin using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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Coagulation factor VII(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542738(CHEMBL4637027)

IC50: 3.65E+3nMAssay Description:Inhibition of human F7a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

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Tissue-type plasminogen activator(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542741(CHEMBL4647950)

IC50: 3.70E+3nMAssay Description:Inhibition of human tPa using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Prostaglandin G/H synthase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542738(CHEMBL4637027)

IC50: 4.30E+3nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair

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Prothrombin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542741(CHEMBL4647950)

IC50: 7.21E+3nMAssay Description:Inhibition of human thrombin using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Complement factor D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542741(CHEMBL4647950)

IC50: 8.92E+3nMAssay Description:Inhibition of human complement FD by TR-FRET assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Coagulation factor X(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542741(CHEMBL4647950)

IC50: 1.12E+4nMAssay Description:Inhibition of human F10a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Coagulation factor IX(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542741(CHEMBL4647950)

IC50: 1.34E+4nMAssay Description:Inhibition of human F9a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Coagulation factor VII(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542741(CHEMBL4647950)

IC50: 1.67E+4nMAssay Description:Inhibition of human F7a using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Plasminogen(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542741(CHEMBL4647950)

IC50: 1.74E+4nMAssay Description:Inhibition of human plasmin using fluorescent peptide as substrate by florescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Bile salt export pump(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50542738(CHEMBL4637027)

IC50: 2.80E+4nMAssay Description:Inhibition of BSEP (unknown origin)More data for this Ligand-Target Pair

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