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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50076479(CHEMBL3235901)
Affinity DataKi:  7.10E+4nMAssay Description:Inhibition of Cys5-LDEETGEFL-NH2 binding to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase GCN5(Saccharomyces cerevisiae S288c)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50076479(CHEMBL3235901)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50076479(CHEMBL3235901)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction expressed in Escherichia coli BL21 codon plus cells using FITC-beta-DEETGEF-OH ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone acetyltransferase GCN5(Saccharomyces cerevisiae S288c)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50076479(CHEMBL3235901)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50076479(CHEMBL3235901)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of FAM-LDEETGEFL-NH2 binding to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50076479(CHEMBL3235901)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of FAM-LDEETGEFL-NH2 binding to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50076479(CHEMBL3235901)
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) by surface plasmon resonance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50076479(CHEMBL3235901)
Affinity DataKd:  2.90E+3nMAssay Description:Binding affinity to human KEAP1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50076479(CHEMBL3235901)
Affinity DataKd:  2.90E+3nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction assessed as equilibrium dissociation constant using FITC-betaAla-DEETGEF-OH as ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50076479(CHEMBL3235901)
Affinity DataEC50:  2.90E+3nMAssay Description:Inhibition of Keap1 (unknown origin) interaction to Nrf2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50076479(CHEMBL3235901)
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity to human KEAP1 by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50076479(CHEMBL3235901)
Affinity DataKd:  2.90E+3nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) interaction assessed as compound's equilibrium dissociation constant after 60 mins by fluorescence anisotro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed