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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
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Target
Sterol O-acyltransferase 1
(Homo sapiens (Human))
TBA
Ligand
BDBM50041735
(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
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Affinity Data
IC50: 9nM
Assay Description:
Inhibition of human SOAT1 expressed in mouse AC29 cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
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PubMed
PDB
3D Structure (crystal)
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Target
Acyl-CoA:cholesterol acyltransferase
(Oryctolagus cuniculus)
Warner-Lambert
Curated by
ChEMBL
Ligand
BDBM50041735
(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
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Affinity Data
IC50: 37nM
Assay Description:
Tested for in vitro inhibition against Acyl coenzyme A:cholesterol acyltransferase of intestinal microsomes in cholesterol-fed rabbits
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Acyl-CoA:cholesterol acyltransferase
(Oryctolagus cuniculus)
Warner-Lambert
Curated by
ChEMBL
Ligand
BDBM50041735
(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 52nM
Assay Description:
In vitro inhibitory activity against ACAT was determined in rabbit intestinal microsome from cholesterol-fed animals
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Acyl-CoA:cholesterol acyltransferase
(Oryctolagus cuniculus)
Warner-Lambert
Curated by
ChEMBL
Ligand
BDBM50041735
(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 52nM
Assay Description:
Tested for in vitro inhibition against Acyl coenzyme A:cholesterol acyltransferase of intestinal microsomes in cholesterol-fed rabbits
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Sterol O-acyltransferase 2
(Homo sapiens (Human))
TBA
Ligand
BDBM50041735
(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
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Copy InChI
Affinity Data
IC50: 368nM
Assay Description:
Inhibition of human SOAT2 expressed in mouse AC29 cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI