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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from human G...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50:  568nMAssay Description:Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human hERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 by high-throughput fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19 by high-throughput fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 by high-throughput fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 by high-throughput fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 by high-throughput fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataEC50:  56nMAssay Description:Agonist activity at mouse GPR119 overexpressed in HEK293S cells assessed as change in cAMP level after 45 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human GPR119 overexpressed in HEK293S cells assessed as change in cAMP level after 45 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human GPR119 receptor over expressed in HEK293S cells assessed as increase in cAMP level after 45 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataEC50:  56nMAssay Description:Agonist activity at mouse GPR119 receptor assessed as increase in cAMP level after 45 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed