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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetCaspase-1(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50:  38nMAssay Description:Inhibition of caspase-1 in human THP1 cells assessed as decrease in LPS-induced IL-1beta secretion after overnight incubation by sandwich immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50:  160nMAssay Description:Inhibition of caspase-1 in human monocyte-derived macrophages assessed as decrease in LPS-induced IL-1beta secretion after 24 hrs by sandwich immunoa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-5(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50:  2.98E+3nMAssay Description:Inhibition of human recombinant caspase-5 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant caspase-8 using Ac-IETD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant caspase-3 using Ac-DEVD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant caspase-7 using Ac-DEVD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Nestl�

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant caspase-6 using Ac-VEID-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed