Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 32 hits in this display
IC50: 72nMAssay Description:Inhibition of FLT3 ITD mutant in human MOLM13 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
JAK3/JAK1(Homo sapiens (Human))West China Hospital Of Sichuan University
Curated by ChEMBL
IC50: 112nMAssay Description:Inhibition of JAK1/JAK3 in human PBMC cells assessed as reduction in IL-2-induced STAT5 phosphorylation by flow cytometryMore data for this Ligand-Target Pair
IC50: 145nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
IC50: 270nMAssay Description:Inhibition of JAK2 V617F mutant in human SET-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
JAK3/JAK1(Homo sapiens (Human))West China Hospital Of Sichuan University
Curated by ChEMBL
IC50: 578nMAssay Description:Inhibition of JAK1/JAK3 in human THP-1 cells assessed as reduction in IL-4-induced STAT6 phosphorylation by flow cytometryMore data for this Ligand-Target Pair