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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 23 hits in this display   

TargetProcathepsin L(Mus musculus)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataKi:  5.30nMAssay Description:Inhibition of mouse Cathepsin L assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataKi:  8nMAssay Description:Inhibition of human recombinant Cathepsin L assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataKi:  117nMAssay Description:Inhibition of human recombinant Cathepsin B assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  0.0180nMAssay Description:Inhibition of human recombinant Cathepsin L assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)
The University Of Jordan

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzain expressed in Pichia pastoris using Z-Phe-Arg-AMC substrate incubated for 30 mins by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  0.367nMAssay Description:Inhibition of human recombinant Cathepsin S assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)
The University Of Jordan

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human cathepsin L using fluorogenic substrate cbz-FR-AMC monitored for 90 to 120 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  5nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFalcipain 2(Plasmodium falciparum)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of FP2' in Plasmodium falciparum trophozoite stage after 1 hr by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain 2(Plasmodium falciparum)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of FP2 in Plasmodium falciparum trophozoite stage after 1 hr by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  47nMAssay Description:Inhibition of recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  79.6nMAssay Description:Inhibition of human recombinant Cathepsin K assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin L2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  140nMAssay Description:Inhibition of human Cathepsin V using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  460nMAssay Description:Inhibition of human Cathepsin V using Z-Phe-Arg-aminomethylcoumarin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  697nMAssay Description:Inhibition of human recombinant Cathepsin V assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human Cathepsin B using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human Cathepsin B using Z-Phe-Arg-aminomethylcoumarin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human Cathepsin H using Arg-aminomethylcoumarin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human Cathepsin H using Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataKoff:  9.00E+3s-1Assay Description:Irreversible inhibition of recombinant human cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed