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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
P2Y purinoceptor 1
(Homo sapiens (Human))
Bristol-Myers Squibb
US Patent
Ligand
BDBM50045619
(CHEMBL3314299 | US9540323, 205 | US9540323, exampl...)
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Affinity Data
Ki: 6.70nM ΔG°: -46.7kJ/mole
pH: 7.4 T: 2°C
Assay Description:
A SPA membrane binding assay was used to identify inhibitors of [33P] 2MeS-ADP binding to cloned human P2Y1 receptors (The P2Y1 receptor membranes we...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
P2Y purinoceptor 1
(Homo sapiens (Human))
Bristol-Myers Squibb
US Patent
Ligand
BDBM50045619
(CHEMBL3314299 | US9540323, 205 | US9540323, exampl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.130nM
Assay Description:
Antagonist activity at P2Y1 receptor in washed human platelets assessed as 1 uM 2-methylthio-ADP-induced calcium flux by FLIPR assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
P2Y purinoceptor 1
(Homo sapiens (Human))
Bristol-Myers Squibb
US Patent
Ligand
BDBM50045619
(CHEMBL3314299 | US9540323, 205 | US9540323, exampl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 210nM
Assay Description:
Antagonist activity at P2Y1 receptor in platelet-enriched human plasma assessed as 10 uM ADP-induced platelet aggregation preincubated for 1 min foll...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI