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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 11 hits in this display   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50593161(CHEMBL5198194)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of wild type SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHistone deacetylase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50593161(CHEMBL5198194)
Affinity DataIC50:  49nMAssay Description:Inhibition of recombinant human HDAC using fluorogenic substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHistone deacetylase 1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50593161(CHEMBL5198194)
Affinity DataIC50:  68nMAssay Description:Inhibition of recombinant his-tagged human HDAC1 using Ac-LeuGlyLys (Ac) AMC substrate preincubated for 5 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50593161(CHEMBL5198194)
Affinity DataIC50:  166nMAssay Description:Inhibition of recombinant his-tagged human HDAC6 using Ac-LeuGlyLys (Ac) AMC substrate preincubated for 5 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50593161(CHEMBL5198194)
Affinity DataIC50:  184nMAssay Description:Inhibition of full length recombinant his-tagged human HDAC2 using Ac-LeuGlyLys (Ac) AMC substrate preincubated for 5 mins followed by substrate addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50593161(CHEMBL5198194)
Affinity DataIC50:  381nMAssay Description:Inhibition of recombinant his-tagged human HDAC3 using Ac-LeuGlyLys (Ac) AMC substrate preincubated for 5 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50593161(CHEMBL5198194)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of recombinant his-tagged human HDAC10 using Ac-ArgHisLys (Ac) Lys (Ac)-AMC substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHistone deacetylase 7(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50593161(CHEMBL5198194)
Affinity DataIC50:  2.68E+3nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LeuGlyLys (TFA)-AMC substrate preincubated for 5 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50593161(CHEMBL5198194)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of recombinant his-tagged human HDAC8 using Boc-Lys (TFA)-AMC substrate preincubated for 5 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHistone deacetylase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50593161(CHEMBL5198194)
Affinity DataIC50:  3.83E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human HDAC5 expressed in HEK293 cells using Ac-LeuGlyLys (TFA)-AMC substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHistone deacetylase 11(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50593161(CHEMBL5198194)
Affinity DataIC50:  2.42E+4nMAssay Description:Inhibition of recombinant his-tagged human HDAC11 using Ac-LeuGlyLys (Ac) AMC substrate preincubated for 5 mins followed by substrate addition and me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed