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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM50173309(CHEMBL3809913 | US10023564, Example 10)
Affinity DataIC50:  70nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50173309(CHEMBL3809913 | US10023564, Example 10)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50173309(CHEMBL3809913 | US10023564, Example 10)
Affinity DataIC50:  5.80E+3nMAssay Description:Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM50173309(CHEMBL3809913 | US10023564, Example 10)
Affinity DataIC50:  6.30E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM50173309(CHEMBL3809913 | US10023564, Example 10)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of GRK5 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50173309(CHEMBL3809913 | US10023564, Example 10)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50173309(CHEMBL3809913 | US10023564, Example 10)
Affinity DataIC50: >1.00E+5nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In DepthDetails US Patent