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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
9
hits in this display
Target
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(Homo sapiens (Human))
G1 Therapeutics
US Patent
Ligand
BDBM601954
(8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfony...)
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Affinity Data
IC50: 3nM
Assay Description:
Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human))
G1 Therapeutics
US Patent
Ligand
BDBM601954
(8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfony...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cyclin-T1/Cyclin-dependent kinase 9
(Homo sapiens (Human))
G1 Therapeutics
US Patent
Ligand
BDBM601954
(8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfony...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human))
G1 Therapeutics
US Patent
Ligand
BDBM601954
(8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfony...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6nM
Assay Description:
Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cyclin-dependent kinase 7
(Homo sapiens (Human))
G1 Therapeutics
US Patent
Ligand
BDBM601954
(8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfony...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 16nM
Assay Description:
Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cyclin-dependent kinase 1
(Homo sapiens (Human))
G1 Therapeutics
US Patent
Ligand
BDBM601954
(8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfony...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 42nM
Assay Description:
Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cyclin-dependent kinase 3/G1/S-specific cyclin-E1
(Homo sapiens (Human))
G1 Therapeutics
US Patent
Ligand
BDBM601954
(8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfony...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 57nM
Assay Description:
Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3
(Homo sapiens (Human))
G1 Therapeutics
US Patent
Ligand
BDBM601954
(8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfony...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 123nM
Assay Description:
Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human))
G1 Therapeutics
US Patent
Ligand
BDBM601954
(8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfony...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 137nM
Assay Description:
Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI