Home
About
Info
Download
WebServices
Contact
Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
20
hits in this display
Target
Histone deacetylase 3
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.600nM
Assay Description:
Inhibition of recombinant human FLAG-tagged HDAC3 expressed in human HEK293F cells co-expressing His6-tagged SMRT (1 to 899 residues) using Fluor-de-...
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 1
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2nM
Assay Description:
Inhibition of recombinant human C-terminal FLAG-tagged HDAC1 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 2
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7nM
Assay Description:
Inhibition of recombinant human C-terminal FLAG-tagged HDAC2 expressed in human HEK293F cells using Fluor-de-lys substrate as substrate incubated for...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 3
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 12nM
Assay Description:
Inhibition of HDAC3 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 1
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 13nM
Assay Description:
Inhibition of HDAC1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 2
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 18nM
Assay Description:
Inhibition of HDAC2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 1/2/3/8
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 200nM
Assay Description:
Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 6
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 680nM
Assay Description:
Inhibition of HDAC6 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 1/2/3/8
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 710nM
Assay Description:
Inhibition of class 1 HDAC in quiescent human primary T-cell model of VSV-G pseudotyped HIV-1 latency assessed as reactivation of HIV latency incubat...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 1/2/3/8
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
TBA
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.00E+3nM
Assay Description:
Inhibition of hERG potassium channel incubated for 4 hrs by fluorescence polarization assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
PubMed
Copy BDB DOI
Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Irbm/Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.50E+3nM
Assay Description:
Inhibition of CYP2C9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 6
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.50E+3nM
Assay Description:
Inhibition of C-terminal FLAG-tagged HDAC6 expressed in mammalian cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 3
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.50E+3nM
Assay Description:
Inhibition of human C-terminal FLAG-tagged HDAC3 in HEK293 cells
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 2
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.50E+3nM
Assay Description:
Inhibition of human C-terminal FLAG-tagged HDAC2 in HEK293 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 1
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.50E+3nM
Assay Description:
Inhibition of human C-terminal FLAG-tagged HDAC1 in HEK293 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 7
(Homo sapiens (Human))
Irbm/Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of wild type His-tagged HDAC7 catalytic domain T515-L952 expressed in Escherichia coli
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 5
(Homo sapiens (Human))
Irbm/Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of wild type His-tagged HDAC5 catalytic domain T678-L1122 expressed in Escherichia coli
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 8
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of HDAC8 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 8
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50258579
((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of C-terminal His-tagged HDAC8 expressed in Escherichia coli
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI