Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234576(US9353089, Table 8, Compound 1)
Affinity DataIC50:  12nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM50446323(CHEMBL588662)
Affinity DataIC50:  12nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin IV [1-448](Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234576(US9353089, Table 8, Compound 1)
Affinity DataIC50:  45nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin E(Homo sapiens (Human))
Saint Louis University

US Patent
LigandPNGBDBM234576(US9353089, Table 8, Compound 1)
Affinity DataIC50:  99nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Saint Louis University

US Patent
LigandPNGBDBM234576(US9353089, Table 8, Compound 1)
Affinity DataIC50:  385nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Saint Louis University

US Patent
LigandPNGBDBM234576(US9353089, Table 8, Compound 1)
Affinity DataIC50:  2.30E+3nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent