Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetCathepsin S(Homo sapiens (Human))
University of California Berkeley

LigandPNGBDBM19483(1, 2, 3 -Triazole Nitrile Inhibitor, 11d | N-[(1S)...)
Affinity DataKi:  18nM ΔG°:  -46.0kJ/molepH: 6.1 T: 2°CAssay Description:The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
University of California Berkeley

LigandPNGBDBM19483(1, 2, 3 -Triazole Nitrile Inhibitor, 11d | N-[(1S)...)
Affinity DataKi:  1.70E+3nM ΔG°:  -34.3kJ/molepH: 6.1 T: 2°CAssay Description:The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University of California Berkeley

LigandPNGBDBM19483(1, 2, 3 -Triazole Nitrile Inhibitor, 11d | N-[(1S)...)
Affinity DataKi: >1.00E+4nM ΔG°: >-29.7kJ/molepH: 6.1 T: 2°CAssay Description:The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University of California Berkeley

LigandPNGBDBM19483(1, 2, 3 -Triazole Nitrile Inhibitor, 11d | N-[(1S)...)
Affinity DataKi: >1.00E+4nM ΔG°: >-29.7kJ/molepH: 6.1 T: 2°CAssay Description:The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
University of California Berkeley

LigandPNGBDBM19483(1, 2, 3 -Triazole Nitrile Inhibitor, 11d | N-[(1S)...)
Affinity DataIC50:  10nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
University of California Berkeley

LigandPNGBDBM19483(1, 2, 3 -Triazole Nitrile Inhibitor, 11d | N-[(1S)...)
Affinity DataIC50:  76nMAssay Description:Inhibition of cathepsin S-mediated antigen presentation in B/T hybridoma cells assessed as IL-2 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University of California Berkeley

LigandPNGBDBM19483(1, 2, 3 -Triazole Nitrile Inhibitor, 11d | N-[(1S)...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of cathepsin L using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed