Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 20 hits in this display   

TargetHistone deacetylase 3(Homo sapiens (Human))
Martin-Luther University Of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  60nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Martin-Luther University Of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
Martin-Luther University Of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  60nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
Martin-Luther University Of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  60nMAssay Description:Inhibition of C-terminal His-tagged human HDAC3 (1 to 428 residues)/N-terminal GST-tagged human NCOR2 (395 to 489 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Martin-Luther University Of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  68.8nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
Martin-Luther University Of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  69nMAssay Description:Allosteric inhibition of C-terminal His-tagged recombinant human HDAC3 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminom...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  90nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  90nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  90nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  90nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  800nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  800nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  800nMAssay Description:Inhibition of C-terminal 6xHis-tagged full-length recombinant human HDAC2 (1 to 488 residues) expressed in Sf9 insect cells by Luminescence Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  800nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Florida Research Foundation

US Patent
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  800nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Martin-Luther University Of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  1.31E+3nMAssay Description:Allosteric inhibition of HDAC3 in HEK293 cell lysates pre-incubated for 2 hrs before acetylated lysine-aminomethyl coumarin-BOC addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Martin-Luther University Of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  2.43E+3nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Martin-Luther University Of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  2.43E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Martin-Luther University Of Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM468609(US10807944, Compound RLS3-43 | US10870618, Compoun...)
Affinity DataIC50:  2.43E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent