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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50:  25nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50:  3.20E+3nMAssay Description:Displacement of BODIPY TR-ADP from GRK5 (unknown origin) preincubated for 10 mins followed by compound addition and measured after 10 to 15 mins by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Gsk

LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50:  3.98E+3nMAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50:  6.30E+3nMAssay Description:Displacement of BODIPY TR-ADP from human GRK2 preincubated for 10 mins followed by compound addition and measured after 10 to 15 mins by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Bos taurus)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50:  1.30E+4nMAssay Description:Displacement of BODIPY TR-ADP from bovine GRK1 (1 to 535 residues) preincubated for 10 mins followed by compound addition and measured after 10 to 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed