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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
77
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Target
Sigma non-opioid intracellular receptor 1
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
Ki: 79nM
Assay Description:
Displacement of [3H]-pentazocin from the Sigma1 receptor
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Target
Sigma intracellular receptor 2
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
Ki: 501nM
Assay Description:
Displacement of [3H]-DTG from the Sigma2 receptor
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
Ki: 3.16E+3nM
Assay Description:
hERG binding assays: Displacement of [3H]-Dofetilide (5 nM final) from hERG membranes obtained from HEK293 cells
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
Ki: 3.31E+3nM
Assay Description:
Activity of compound against Muscarinic acetylcholine receptor M3 (CHRM3) by displacement of 3H-QNB
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Target
Alpha-2A adrenergic receptor
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
Ki: 4.37E+3nM
Assay Description:
Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
Ki: 4.68E+3nM
Assay Description:
Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
Ki: 5.75E+3nM
Assay Description:
Activity of compound against Muscarinic acetylcholine receptor M4 (CHRM4) by displacement of 3H-QNB
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
Ki: 7.50E+3nM
Assay Description:
Inhibition of human ERG expressed in CHO cells
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
Ki: 9.12E+3nM
Assay Description:
Activity of compound against Muscarinic acetylcholine receptor M1 (CHRM1) by displacement of 3H-QNB
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Target
Alpha-2C adrenergic receptor
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
Ki: 1.00E+4nM
Assay Description:
Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscine
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Ki: 2.19E+4nM
Assay Description:
Activity of compound against Muscarinic acetylcholine receptor M5 (CHRM5) by displacement of 3H-QNB
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Target
Alpha-2B adrenergic receptor
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
Ki: 3.16E+4nM
Assay Description:
Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine
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Target
Falcipain 2
(Plasmodium falciparum)
Delhi Institute Of Pharmaceutical Sciences And Research
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 20nM
Assay Description:
Inhibition of falcipain-2 in chloroquine sensitive Plasmodium falciparum MRC-02 schizont stage infected in human erythrocytes assessed as reduction i...
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Target
Dihydrofolate reductase
(Bos taurus (Cattle))
P.D. Patel Institute of Applied Sciences
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 30nM
Assay Description:
Inhibition of bovine liver DHFR
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Target
Dihydrofolate reductase
(Bos taurus (Cattle))
P.D. Patel Institute of Applied Sciences
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 30nM
Assay Description:
Inhibition of bovine liver DHFR pre-incubated 2 mins before dihydrofolic acid substrate addition and measured over 10 mins in presence of NADPH
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Target
Dihydrofolate reductase
(Bos taurus (Cattle))
P.D. Patel Institute of Applied Sciences
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 31.3nM
Assay Description:
Inhibition of bovine liver DHFR using FH2 as substrate preincubated for 2 mins followed by substrate addition
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Target
Dihydrofolate reductase
(Bos taurus (Cattle))
P.D. Patel Institute of Applied Sciences
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 31.3nM
Assay Description:
Inhibition of bovine liver DHFR using FH2 as substrate preincubated for 2 mins followed by substrate addition in presence of NADPH
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Target
Dihydrofolate reductase
(Bos taurus (Cattle))
P.D. Patel Institute of Applied Sciences
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
Copy SMILES
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Affinity Data
IC50: 31.3nM
Assay Description:
Inhibition of bovine liver DHFR using FH2 as substrate incubated for 2 mins followed by substrate addition
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Target
Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 76.5nM
Assay Description:
Inhibitory activity against beta-hematin formation
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Target
Spike glycoprotein
(2019-nCoV)
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 160nM
Assay Description:
Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...
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Target
Falcipain-2
(Plasmodium falciparum)
Delhi Institute Of Pharmaceutical Sciences And Research
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 200nM
Assay Description:
Inhibition of falcipain-2 in chloroquine resistant Plasmodium falciparum RKL9 schizont stage infected in human erythrocytes assessed as reduction in ...
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Target
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human))
TBA
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 270nM
Assay Description:
Inhibition of mTOR (unknown origin)
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Target
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human))
TBA
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 270nM
Assay Description:
Inhibition of mTOR (unknown origin) activation
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Target
Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 400nM
Assay Description:
Inhibition of beta-hematin polymerization
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Target
Angiotensin-converting enzyme 2
(Homo sapiens (Human))
TBA
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 1.13E+3nM
Assay Description:
Inhibition of human recombinant ACE2 at 50 uM using (7Mca-Y-V-A- D -A-P- K(Knp) as a flurogenic substrate measured after 10 mins by fluorescence base...
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Target
Ribosyldihydronicotinamide dehydrogenase [quinone]
(Homo sapiens (Human))
University Of Manchester And Manchester Cancer Research Center
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 1.50E+3nM
Assay Description:
Inhibition of human recombinant NQO2
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3D Structure (crystal)
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 2.50E+3nM
Assay Description:
Inhibition of human cloned ERG
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 2.50E+3nM
Assay Description:
Inhibition of human ERG expressed in HEK293 cells assessed as reduction in tail current at membrane potential of +20 mV
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 2.50E+3nM
Assay Description:
Inhibitory concentration against IKr potassium channel
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 2.51E+3nM
Assay Description:
Inhibition of human ERG
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Target
Angiotensin-converting enzyme 2
(Homo sapiens (Human))
TBA
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 5.47E+3nM
Assay Description:
This is a review article.
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Amyloid-beta precursor protein
(Homo sapiens (Human))
University Of Lille
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 7.00E+3nM
Assay Description:
Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 40 residues) production measured after 2...
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Beta-secretase 1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 7.00E+3nM
Assay Description:
Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 40) level after 24 hrs by ELISA met...
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Replicase polyprotein 1ab
(2019-nCoV)
TBA
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 7.28E+3nM
Assay Description:
Inhibition of SARS-CoV-2 main protease
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Replicase polyprotein 1ab
(2019-nCoV)
TBA
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 7.28E+3nM
Assay Description:
Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...
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Replicase polyprotein 1ab
(2019-nCoV)
TBA
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 1.20E+4nM
Assay Description:
Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...
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Beta-secretase 1
(Homo sapiens (Human))
Universit£
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Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 1.27E+4nM
Assay Description:
Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 42) level after 24 hrs by ELISA met...
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Amyloid-beta precursor protein
(Homo sapiens (Human))
University Of Lille
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 1.28E+4nM
Assay Description:
Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 42 residues) production measured after 2...
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Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
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Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 1.50E+4nM
Assay Description:
Inhibition of hematin polymerization
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Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
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Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 1.52E+4nM
Assay Description:
Antiplasmodial activity as inhibition of beta-hematin against Plasmodium yoelii N67 infected Swiss mice (Mus musculus) erythrocytes
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Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
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Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 1.54E+4nM
Assay Description:
Inhibition of beta-hematin formation after 16 hrs
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Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
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Ligand
BDBM22985
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IC50: 3.80E+4nM
Assay Description:
Inhibition of beta-hematin formation
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DNA ligase A
(Mycobacterium tuberculosis)
India Central Drug Research Institute
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 4.60E+4nM
pH: 8.0 T: 2°C
Assay Description:
The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...
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DNA ligase A
(Mycobacterium tuberculosis)
India Central Drug Research Institute
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 4.60E+4nM
pH: 8.0 T: 2°C
Assay Description:
The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...
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Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
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Ligand
BDBM22985
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IC50: 4.63E+4nM
Assay Description:
Inhibition of lipid-induced beta-hematin formation
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Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
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ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 6.00E+4nM
Assay Description:
Inhibition of 1-monooleoyl glycerol induced beta-hematin formation
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Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
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ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 7.50E+4nM
Assay Description:
Inhibition of beta-hematin formation in Plasmodium falciparum
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Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
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ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 7.65E+4nM
Assay Description:
Inhibition of 1-monooleoyl glycerol (MOG) induced beta-hematin formation
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ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 1.04E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: >1.35E+5nM
Assay Description:
Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...
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MO15-related protein kinase Pfmrk
(Plasmodium falciparum)
Walter Reed Army Institute Of Research
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 1.50E+5nM
Assay Description:
Inhibition of Plasmodium falciparum cyclin-dependent kinase
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Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
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ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 2.52E+5nM
Assay Description:
Inhibition of Tween 20-induced beta-hematin formation by colorimetric assay
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Cytochrome P450 3A4
(Homo sapiens (Human))
Jadavpur University
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 3.50E+5nM
Assay Description:
Inhibition of CYP3A4
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Phosphoethanolamine N-methyltransferase
(Plasmodium falciparum)
Washington University
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 5.54E+5nM
Assay Description:
Inhibition of Plasmodium falciparum phosphoethanolamine methyltransferase using phospethanolamine as substrate by radiochemical assay in presence of ...
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DNA ligase
(Bacteriophage T4)
India Central Drug Research Institute
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 1.60E+6nM
pH: 7.6 T: 2°C
Assay Description:
The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...
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DNA ligase
(Bacteriophage T4)
India Central Drug Research Institute
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 1.60E+6nM
pH: 7.6 T: 2°C
Assay Description:
The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...
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Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
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ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 5.90E+6nM
Assay Description:
Inhibition of beta-hematin formation
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Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 9.10E+8nM
Assay Description:
Inhibition of beta-hematin formation by BHIA assay
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Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 1.69E+9nM
Assay Description:
Inhibition of beta-hematin formation
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Histidine-rich protein PFHRP-II
(Plasmodium falciparum)
Universit£
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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IC50: 2.56E+9nM
Assay Description:
Inhibition of beta-hematin formation by BHIA assay
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Integrase
(Human immunodeficiency virus 1)
TBA
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
IC50: 4.07E+12nM
Assay Description:
Inhibition of Human immunodeficiency virus 1 integrase strand transfer activity
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Replicase polyprotein 1ab
(HCoV-229E)
University of Bonn
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
EC50: 3.30E+3nM
Assay Description:
This is a review article.
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Orf1a protein
(MERS-CoV)
University of Bonn
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
EC50: 6.27E+3nM
Assay Description:
This is a review article.
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Replicase polyprotein 1ab
(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University of Bonn
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
EC50: 6.53E+3nM
Assay Description:
This is a review article.
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Target
Replicase polyprotein 1ab
(2019-nCoV)
TBA
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
EC50: 7.35E+3nM
Assay Description:
SARS-CoV-2 was provided by Korea Centers for Disease Control and Prevention (KCDC) . Vero cells were acquired from the ATCC and maintained in the Dul...
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Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human))
Goethe University
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
EC50: 4.70E+4nM
Assay Description:
Agonist activity at Gal4-fused human Nurr1 LBD expressed in HEK293T cells co-expressing firefly luciferase assessed as luciferase activity incubated ...
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Nuclear receptor subfamily 4 group A member 2
(Homo sapiens (Human))
Goethe University
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
EC50: 5.00E+4nM
Assay Description:
Agonist activity at Nurr1 ligand binding domain (unknown origin) measured by Gal4-based reporter gene assay
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C-X-C chemokine receptor type 4
(Homo sapiens (Human))
TBA
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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EC50: 6.50E+3nM
Assay Description:
Antagonist activity at CXCR4 receptor in human MIA PaCa-2 cells assessed as reduction in forskolin-stimulated inhibition of cAMP production
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Orf1a protein
(MERS-CoV)
University of Bonn
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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EC50: 3.00E+3nM
Assay Description:
This is a review article.
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Angiotensin-converting enzyme 2
(Homo sapiens (Human))
TBA
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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EC50: 8.80E+3nM
Assay Description:
This is a review article.
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Calcium-dependent protein kinase 1
(Plasmodium Falciparum)
The Scripps Research Institute
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
EC50: 68nM
pH: 7.5 T: 2°C
Assay Description:
This parasite proliferation assay, a modification of published DNA intercalating fluorescent dye-based assay, was adapted to 384-well plate format an...
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Riboflavin-binding protein
(Gallus gallus)
Calvin College
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
Kd: 2.10E+3nM
pH: 7.4
Assay Description:
Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 7.4 in phosphate buffer by isothermal titration calori...
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Major prion protein
(Homo sapiens (Human))
Institut F£R Molekularbiologie Und Biophysik
Curated by
ChEMBL
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
EC50: 4.00E+3nM
Assay Description:
Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cells
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Replicase polyprotein 1ab
(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University of Bonn
Ligand
BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
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Affinity Data
EC50: 4.10E+3nM
Assay Description:
This is a review article.
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