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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556329(N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)...)
Affinity DataIC50:  0.160nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556329(N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)...)
Affinity DataIC50:  4.72nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were respectively dissolved in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556329(N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)...)
Affinity DataIC50:  368nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556329(N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)...)
Affinity DataIC50:  705nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent