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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetAurora kinase B-B(Xenopus laevis (African clawed frog))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  3nMpH: 7.6Assay Description:The ATP-KM value of the complex is 61 uM. The kinase assays are run in the presence of 100 uM ATP using 10 uM of a substrate peptide. pAUB-IN847 was ...More data for this Ligand-Target Pair
TargetAurora kinase B-B(Xenopus laevis (African clawed frog))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  3nMAssay Description:Inhibition of Xenopus laevis Aurora Kinase BMore data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human full-length His-tagged Aurora B expressed in baculovirus expression system using 5-FAM-LRRASLG-CONH2 as substrate pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  4nMAssay Description:Inhibition of human MEK2More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  4nMAssay Description:Inhibition of human MEK2More data for this Ligand-Target Pair
TargetAurora kinase C(Homo sapiens (Human))TBA
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Aurora CMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  25nMAssay Description:Inhibition of human MEK1More data for this Ligand-Target Pair
TargetAurora kinase A-A(Xenopus laevis)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  25nMAssay Description:Inhibition of Xenopus laevis Aurora Kinase AMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  25nMpH: 7.6Assay Description:The ATP-KM value of the complex is 61 uM. The kinase assays are run in the presence of 100 uM ATP using 10 uM of a substrate peptide. pAUB-IN847 was ...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))TBA
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  25nMAssay Description:Inhibition of human Aurora AMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  25nMAssay Description:Inhibition of human MEK1More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))TBA
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  25nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed