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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
hits in this display
Target
Complement factor B
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM160485
(US9682968, Example-27-4a (+))
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Affinity Data
IC50: 0.0100nM
Assay Description:
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Complement factor B
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM160486
(US9682968, Example-27-4b (-))
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Affinity Data
IC50: 1.70nM
Assay Description:
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Complement factor B
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM50540314
(CHEMBL4639592)
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Copy InChI
Affinity Data
IC50: 6nM
Assay Description:
Inhibition of human serine protease factor B by TR-FRET based competition binding assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Complement factor B
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM289502
(US10093663, Example 27-4a)
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Affinity Data
IC50: 9nM
pH: 7.4 T: 2°C
Assay Description:
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Complement factor B
(Mus musculus)
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50540314
(CHEMBL4639592)
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Affinity Data
IC50: 80nM
Assay Description:
Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Complement factor B
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM50540314
(CHEMBL4639592)
Copy SMILES
Copy InChI
Affinity Data
IC50: 140nM
Assay Description:
Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Complement factor B
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM289503
(US10093663, Example 27-4b)
Copy SMILES
Affinity Data
IC50: 1.70E+3nM
pH: 7.4 T: 2°C
Assay Description:
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI