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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetSerine/threonine-protein kinase B-raf(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614406(US11964950, Compound K-10 | US20230270730, Compoun...)
Affinity DataIC50:  8nMAssay Description:The test compound, BRAF (Eurofins Genomics KK.) and MEK1 (Thermo Fisher Scientific Inc.) were mixed in ATP-containing buffer and reacted for 90 minut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614406(US11964950, Compound K-10 | US20230270730, Compoun...)
Affinity DataIC50:  8nMAssay Description:The BRAF-inhibiting activity of the compounds listed in Table 3 below was evaluated by the time-resolved fluorescence-fluorescence resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614406(US11964950, Compound K-10 | US20230270730, Compoun...)
Affinity DataIC50:  128nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614406(US11964950, Compound K-10 | US20230270730, Compoun...)
Affinity DataIC50:  128nMAssay Description:The test compound, CRAF (Thermo Fisher Scientific Inc.), MEK1 (Thermo Fisher Scientific Inc.) and ERK2 (Carna Biosciences, Inc.) were mixed in ATP-co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent