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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Serine/threonine-protein kinase B-raf
(Human)
Chugai Seiyaku Kabushiki Kaisha
US Patent
Ligand
BDBM614406
(US11964950, Compound K-10 | US20230270730, Compoun...)
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Affinity Data
IC50: 8nM
Assay Description:
The test compound, BRAF (Eurofins Genomics KK.) and MEK1 (Thermo Fisher Scientific Inc.) were mixed in ATP-containing buffer and reacted for 90 minut...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Serine/threonine-protein kinase B-raf
(Human)
Chugai Seiyaku Kabushiki Kaisha
US Patent
Ligand
BDBM614406
(US11964950, Compound K-10 | US20230270730, Compoun...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 8nM
Assay Description:
The BRAF-inhibiting activity of the compounds listed in Table 3 below was evaluated by the time-resolved fluorescence-fluorescence resonance energy t...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Mitogen-activated protein kinase kinase kinase 1
(Human)
Chugai Seiyaku Kabushiki Kaisha
US Patent
Ligand
BDBM614406
(US11964950, Compound K-10 | US20230270730, Compoun...)
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Affinity Data
IC50: 128nM
Assay Description:
The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Dual specificity mitogen-activated protein kinase kinase 1
(Human)
Chugai Seiyaku Kabushiki Kaisha
US Patent
Ligand
BDBM614406
(US11964950, Compound K-10 | US20230270730, Compoun...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 128nM
Assay Description:
The test compound, CRAF (Thermo Fisher Scientific Inc.), MEK1 (Thermo Fisher Scientific Inc.) and ERK2 (Carna Biosciences, Inc.) were mixed in ATP-co...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI