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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Beta-secretase 1
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM372750
((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(...)
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Affinity Data
IC50: 7.98nM
Assay Description:
The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Beta-secretase 2
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM372750
((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(...)
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Copy InChI
Affinity Data
IC50: 45.5nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cathepsin D
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM372750
((1S,5S,6S)-3-amino-5-(2-fluoro-5-((Z)-2-fluoro-2-(...)
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Copy InChI
Affinity Data
IC50: 1.07E+5nM
Assay Description:
Recombinant Cat D was expressed in CHO cells. The assay buffer for CatD is 0.05M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) i...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI