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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 0.150nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 0.770nMAssay Description:Displacement of [3H]imipramine from human 5HT transporterMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 1nMAssay Description:Displacement of [3H]-imipramine from human serotonin transporter expressed in HEK-293 cell membranes after 30 mins by scintillation countingMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 1.30nMMore data for this Ligand-Target Pair

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PDB

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 1.40nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 1.90nMAssay Description:Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 2nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H1 receptor(RAT)
Novo Industri

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 2nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 2.10nMAssay Description:Displacement of [3H]imipramine from human recombinant SERT expressed in CHO cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 2.10nMAssay Description:Displacement of [3H]imipramine from human SERT expressed in CHO cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 2.5nMAssay Description:Displacement of [3H]-imipramine from human serotonin transporter expressed in HEK293 cells membranes incubated for 30 mins by microbeta scintillation...More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Sodium-dependent serotonin transporter(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 5nMAssay Description:Binding affinity to Serotonin transporter using [3H]-paroxetine as radioligand in stably transfected NIH3T3 cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 5nMAssay Description:Binding affinity towards Serotonin transporter using [3H]-paroxetine as radioligandMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 5.70nMAssay Description:Inhibition of human SERT I179C mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 7.57nMAssay Description:Inhibition of [3H]serotonin reuptake at serotonin transporterMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 8.70nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 9.5nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Histamine H1 receptor(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 10nMAssay Description:Binding affinity to H1 receptor (unknown origin)More data for this Ligand-Target Pair

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Norepinephrine transporter(RAT)
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 11nMMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/TrEMBL
GoogleScholar

Transporter(Rattus norvegicus)
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 12nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) in rat synaptosomesMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
GoogleScholar

Sodium-dependent noradrenaline transporter(MOUSE)
Mcneil Pharmaceutical

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 12nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair

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UniProtKB/TrEMBL
GoogleScholar

Transporter(Rattus norvegicus)
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 12nMAssay Description:Inhibition of norepinephrine (NE) into rat brain synaptosomesMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
GoogleScholar

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 14.2nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
GoogleScholar

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 14.2nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 16nMAssay Description:Binding affinity towards Norepinephrine transporter using [3H]-nisoxitine as radioligandMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Sodium-dependent noradrenaline transporter(MOUSE)
Mcneil Pharmaceutical

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 16nMAssay Description:Binding affinity to Norepinephrine transporter using [3H]-nisoxatine as radioligand in stably transfected NIH3T3 cellsMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Histamine H1 receptor(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 16nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 19nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 20nMMore data for this Ligand-Target Pair

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PDB

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 20nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 20nMAssay Description:Displacement of [3H]citalopram from serotonin transporterMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 20nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair

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Details PubMed DrugBank
PDB

Serotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 23nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H1 receptor(RAT)
Novo Industri

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 26nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 29nMAssay Description:Displacement of [3H]-citalopram from SERT in rat cortex tissue measured after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 29nMAssay Description:Displacement of [3H]-citalopram from SERT in rat cortex tissue incubated for 60 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 30.9nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
GoogleScholar

Histamine H1 receptor(RAT)
Novo Industri

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 31nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 31nMAssay Description:Inhibition of wild-type human SERT expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5HT ...More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-1A adrenergic receptor(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 32nMMore data for this Ligand-Target Pair

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Norepinephrine transporter(RAT)
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 33.1nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 37nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Histamine H1 receptor(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 37nMMore data for this Ligand-Target Pair

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Reactome pathway
UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M1(Homo sapiens (Human))
Mayo Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 42nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
GoogleScholar

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 42nMAssay Description:Inhibition of serotonin (5-HT) uptake into rat brain synaptosomesMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
GoogleScholar

Sodium-dependent dopamine transporter(MOUSE)
Mcneil Pharmaceutical

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 42nMAssay Description:Tested in vitro for serotonin(5-HT) neuronal uptake inhibitionMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 42nMAssay Description:Inhibition the uptake of tritiated serotonin (5-HT) by the serotonin transporter SERT in rat synaptosomesMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M2(Homo sapiens (Human))
University of Arizona

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 46nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))TBA

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 46nMAssay Description:In vitro binding affinity at Alpha-1 adrenergic receptor by radioligand binding assay using [3H]prazosinMore data for this Ligand-Target Pair

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Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 51nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

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Muscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mayo Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 60nMMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 65nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor was determined in homogenized rat cortex tissue using [3H]N-methylscopolamine as radioliga...More data for this Ligand-Target Pair

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Norepinephrine transporter(RAT)
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 66nMMore data for this Ligand-Target Pair

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Norepinephrine transporter(RAT)
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 82.2nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M5(Homo sapiens (Human))
Mayo Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 83nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M2(Homo sapiens (Human))
University of Arizona

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 88nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent noradrenaline transporter(BOVINE)
The University of Queensland

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 93.6nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 94nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor using [3H]-ketanserinMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
University of Turku

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 94nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 98nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
University of Turku

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 100nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Sri International

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 102nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
University of Turku

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 106nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Mayo Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 112nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 118nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 142nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 150nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 160nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2A receptor expressed NIH3T3 cellsMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 2C(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 160nMAssay Description:Binding affininity of the compound to 5-hydroxytryptamine 2C receptor using [3H]-Mesulergine as radioligand in stably transfected NIH3T3 cellsMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 160nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2C receptor using [3H]-mesulergine as radioligandMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Sri International

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 160nMMore data for this Ligand-Target Pair

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D(2) dopamine receptor(BOVINE)
TBA

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 180nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University Medical College

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 190nM ΔG°: -38.4kJ/moleT: 2°CAssay Description:The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris�HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5...More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 6(RAT)
National Institute of Neurological Disorders and Stroke

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 190nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 6(RAT)
National Institute of Neurological Disorders and Stroke

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 191nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 6(RAT)
National Institute of Neurological Disorders and Stroke

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 209nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 6(RAT)
National Institute of Neurological Disorders and Stroke

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 209nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Sri International

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 217nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))TBA

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 220nMAssay Description:Binding affinity towards alpha-1 adrenergic receptorMore data for this Ligand-Target Pair

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Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)TBA

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 255nMAssay Description:In vitro binding affinity at Alpha-2 adrenergic receptor in rat cortex by radioligand binding assay using [3H]rauwolscineMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 295nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

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UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M2(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 320nMMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(RAT)
Soochow University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 343nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in Sprague-Dawley rat brain membranes by scintillation counting methodMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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D(3) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 387nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 420nMMore data for this Ligand-Target Pair

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Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
TBA

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 520nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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D(2) dopamine receptor(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 620nMMore data for this Ligand-Target Pair

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D(2) dopamine receptor(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 726nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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D(2) dopamine receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 726nMAssay Description:Binding affinity to Dopamine receptor D2 using [3H]spiperone as radioligand in stably transfected NIH3T3 cellsMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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D(2) dopamine receptor(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 726nMAssay Description:Binding affinity towards dopamine receptor D2 using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 810nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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D(2) dopamine receptor(Rattus norvegicus (rat))
Novo Industri

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 942nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University Medical College

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 1.00E+3nM ΔG°: -34.2kJ/moleT: 2°CAssay Description:The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris�HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5...More data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 1.30E+3nMAssay Description:Inhibition of human SERT I172M mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5...More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sigma intracellular receptor 2(Rattus norvegicus (Rat))
Soochow University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 2.11E+3nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in Sprague-Dawley rat brain membranes in presence of (+)-pentazocine by scintillation counting methodMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M2(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 2.30E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 2.90E+3nMMore data for this Ligand-Target Pair

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D(1A) dopamine receptor(RAT)
Novo Industri

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 3.00E+3nMMore data for this Ligand-Target Pair

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Alpha-2A adrenergic receptor(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 3.10E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 3A(Mus musculus (house mouse))
Sri International

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 3.65E+3nMMore data for this Ligand-Target Pair

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Alpha-2C adrenergic receptor(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 4.60E+3nMMore data for this Ligand-Target Pair

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Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)TBA

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 4.90E+3nMAssay Description:Binding affinity towards alpha-2 adrenergic receptorMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Alpha-2C adrenergic receptor(RAT)
Eli Lilly

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 5.70E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 5.80E+3nMMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 8.50E+3nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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D(1A) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nM ΔG°: >-28.5kJ/moleT: 2°CAssay Description:The composition of the assay buffers was as follows: for 5-HT1AR: 50 mM Tris�HCl, 0.1 mM EDTA, 4 mM MgCl2, 10 lM pargyline, and 0.1% ascorbate; for 5...More data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(MOUSE)
Mcneil Pharmaceutical

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMAssay Description:Tested in vitro for dopamine(DA) neuronal uptake inhibitionMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMAssay Description:Inhibition of dopamine (DA) uptake into rat brain synaptosomesMore data for this Ligand-Target Pair

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Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMAssay Description:Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomesMore data for this Ligand-Target Pair

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NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Novo Industri

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Gamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Novo Industri

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Gamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Novo Industri

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Beta-1 adrenergic receptor(Rattus norvegicus (Rat))
Novo Industri

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Novo Industri

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Novo Industri

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Beta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
GoogleScholar

D(1A) dopamine receptor(BOVINE)
TBA

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Solute carrier family 22 member 3(Homo sapiens (Human))
Medical College Of Georgia

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Ki: 4.20E+4nMAssay Description:TP_TRANSPORTER: inhibition of MPP+ uptake in OCT3-expressing HRPE cellsMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
GoogleScholar

Histamine H1 receptor(RAT)
Novo Industri

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 0.0600nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 0.880nMAssay Description:Displacement of [3H]imipramine from human recombinant 5HT transporter expressed in CHO cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 0.880nMAssay Description:Displacement of [3H]imipramine from human recombinant 5-HT transporter expressed in CHO cellsMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 1.70nMAssay Description:Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 2.60nMAssay Description:Inhibition of human SERT W103A mutant expressed in HEK293 MSR cells assessed as [3H]-5-HT uptake preincubated for 30 mins followed addition of [3H]-5...More data for this Ligand-Target Pair

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UniProtKB/TrEMBL
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Transporter(Rattus norvegicus)
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 2.60nMAssay Description:Norepinephrine transporter activity was determined by the ability of compound to inhibit the neurotransmitter norepinephrine-NE reuptake system using...More data for this Ligand-Target Pair

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Details Article

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 4.10nMAssay Description:Displacement of [3H] imipramine from human recombinant 5-HT transporter measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 4.40nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 5.10nMAssay Description:Inhibition of human SERT expressed in CHO cell membranes assessed as reduction in [3H]serotonin uptake preincubated for 10 mins followed by [3H]serot...More data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 6.80nMAssay Description:Displacement of [3H]imipramin from human recombinant SERT over-expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 7.30nMAssay Description:Inhibition of human 5-HT transporterMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 8nMAssay Description:Inhibition of [3H]5HT uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Histamine H1 receptor(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 27nMAssay Description:Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 29nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 29nMAssay Description:Inhibition of human SERT expressed in HEK293-MSR cells by 5-HT uptake assayMore data for this Ligand-Target Pair

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UniProtKB/TrEMBL
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Transporter(Rattus norvegicus)
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 60nMAssay Description:Inhibition of norepinephrine uptake in synaptosomal preparation fro rat hypothalamus, using [3H]norepinephrineMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 61nMAssay Description:Inhibition of SERT expressed in rat brain synaptosomes assessed as decrease in incorporation of [3H]serotonin measured after 15 mins by scintillation...More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 74nMAssay Description:Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 120nMAssay Description:Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomesMore data for this Ligand-Target Pair

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Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))TBA

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 160nMAssay Description:Concentration of compound for 50% displacement of [3H]WB-4101 from Alpha-1 adrenergic receptor of rat brainMore data for this Ligand-Target Pair

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UniProtKB/TrEMBL
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Transporter(Rattus norvegicus)
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 260nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomesMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 269nMAssay Description:Concentration of compound for 50% displacement of [3H]QNB from Muscarinic acetylcholine receptor in rat brainMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 300nMAssay Description:In vitro inhibition of accumulation of [14C]-5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M5(RAT)
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 300nMAssay Description:Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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D(2) dopamine receptor(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 410nMAssay Description:Binding affinity to dopamine D2 receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Solute carrier family 22 member 2(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 600nMAssay Description:Inhibition of human OCT2 expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assayMore data for this Ligand-Target Pair

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D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 645nMAssay Description:Concentration of compound for 50% displacement of [3H]spiperone from Dopamine receptor in rat brainMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
Emory University

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 810nMAssay Description:Inhibition of 5-HT uptake in synaptosomal preparation from rat corpus striatum, using [3H]5-HTMore data for this Ligand-Target Pair

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UniProtKB/TrEMBL
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Transporter(Rattus norvegicus)
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 1.30E+3nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]-Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair

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Histamine H2 receptor(Cavia porcellus (domestic guinea pig))
Universidad De Valencia

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 1.90E+3nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 3.39E+3nMAssay Description:Inhibition of partially open human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel)More data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 3.39E+3nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 3.39E+3nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 3.39E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 3.39E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 3.39E+3nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 3.40E+3nMAssay Description:Inhibition of hERG K channelMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 3.40E+3nMAssay Description:K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1More data for this Ligand-Target Pair

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Sodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 3.60E+3nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair

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Sodium channel protein type 7 subunit alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 3.60E+3nMAssay Description:Inhibition of Na channel (species unknown)More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Jagiellonian University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 4.05E+3nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair

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Sphingomyelin phosphodiesterase(Homo sapiens)
Furtwangen University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 5.00E+3nMAssay Description:Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates using 3H-sphingomyelin as substrate preincubated for 30 mins followed by m...More data for this Ligand-Target Pair

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Solute carrier family 22 member 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 7.95E+3nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidaseMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 8.30E+3nMAssay Description:Inhibition of voltage-gated L-type Ca channel (species unknown)More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Jagiellonian University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 8.30E+3nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair

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Solute carrier family 22 member 2(RAT)
Kyoto University Hospital

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 9.90E+3nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake (TEA: 50 uM) in OCT2-expressing MDCK cellsMore data for this Ligand-Target Pair

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Multidrug and toxin extrusion protein 1(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 1.00E+4nMAssay Description:Inhibition of human MATE1 expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assayMore data for this Ligand-Target Pair

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Solute carrier family 22 member 1(RAT)
Kyoto University Hospital

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 1.60E+4nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake (TEA: 50 uM) in OCT1-expressing MDCK cellsMore data for this Ligand-Target Pair

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Solute carrier family 22 member 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 1.71E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 2.00E+4nMAssay Description:Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum, using [3H]dopamineMore data for this Ligand-Target Pair

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Voltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 2.20E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair

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Pleiotropic ABC efflux transporter of multiple drugs(Saccharomyces cerevisiae S288c)
Wroclaw Medical University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 2.20E+4nMAssay Description:Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assayMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 2.56E+4nMAssay Description:Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair

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Solute carrier family 22 member 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 3.70E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assayMore data for this Ligand-Target Pair

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Cytochrome P450 2J2(Homo sapiens (Human))
Tongji University

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: >5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair

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Multidrug and toxin extrusion protein 2(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: >1.00E+5nMAssay Description:Inhibition of human MATE2-K expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assayMore data for this Ligand-Target Pair

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ATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

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Bile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair

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ATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

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ATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair

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Bile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair

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Bromodomain-containing protein 4(Homo sapiens (Human))
The University Of Hong Kong

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 6.47E+5nMAssay Description:Displacement of SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K(Biotin) from Europium chelated human BRD4 bromodomain 2 (342 to 460 residues) measu...More data for this Ligand-Target Pair

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Bromodomain-containing protein 4(Homo sapiens (Human))
The University Of Hong Kong

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

IC50: 1.01E+6nMAssay Description:Displacement of SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K(Biotin) from Europium chelated human BRD4 bromodomain 1 (49 to 170 residues) measur...More data for this Ligand-Target Pair

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Envelope glycoprotein(Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zair...)
University Of Oxford

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

Kd: 5.84E+5nMAssay Description:Binding affinity to EBOV Mayinga, Zaire, 1976 envelope glycoprotein extracellular domain H613A mutant tagged with His/foldon trimerization sequence f...More data for this Ligand-Target Pair

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Major prion protein(Homo sapiens (Human))
Institut F£R Molekularbiologie Und Biophysik

Curated by ChEMBL

BDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)

EC50: 1.00E+4nMAssay Description:Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cellsMore data for this Ligand-Target Pair

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