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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
13
hits in this display
Target
Histamine H4 receptor
(Homo sapiens (Human))
Gedeon Richter
Curated by
ChEMBL
Ligand
BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)
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Affinity Data
Ki: 90nM
Assay Description:
Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells
More data for this Ligand-Target Pair
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Gedeon Richter
Curated by
ChEMBL
Ligand
BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 316nM
Assay Description:
Displacement of [3H]histamine from human histamine H4 receptor
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
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antibodypedia
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Ligand Info
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KEGG
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In Depth
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Article
PubMed
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Gedeon Richter
Curated by
ChEMBL
Ligand
BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 316nM ΔG°: -38.6kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
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antibodypedia
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Ligand Info
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KEGG
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Article
PubMed
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Gedeon Richter
Curated by
ChEMBL
Ligand
BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)
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Copy InChI
Affinity Data
Ki: 316nM
Assay Description:
Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2
More data for this Ligand-Target Pair
Target Info
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antibodypedia
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Article
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Gedeon Richter
Curated by
ChEMBL
Ligand
BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 377nM
More data for this Ligand-Target Pair
Target Info
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KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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Article
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Target
Hrh3 protein
(RAT)
Schering-Plough Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)
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Affinity Data
Ki: 440nM
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H3 receptor
(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)
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Affinity Data
Ki: 825nM
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H1 receptor
(RAT)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)
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Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
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KEGG
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PC sid
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In Depth
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Article
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Target
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig))
Hoechst Pharmaceutical Research Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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CHEMBL
KEGG
PC cid
PC sid
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histamine H4 receptor
(Homo sapiens (Human))
Gedeon Richter
Curated by
ChEMBL
Ligand
BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
KEGG
PC cid
PC sid
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histamine H2 receptor
(Homo sapiens (Human))
University Of Regensburg
Curated by
ChEMBL
Ligand
BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)
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Affinity Data
Ki: 2.51E+4nM
Assay Description:
Displacement of [125I]iodoaminopotentidine from human histamine H2 receptor expressed in CHO cells
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
DrugBank
antibodypedia
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Ligand Info
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CHEMBL
KEGG
PC cid
PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Histamine H4 receptor
(Homo sapiens (Human))
Gedeon Richter
Curated by
ChEMBL
Ligand
BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 1.59E+3nM
Assay Description:
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
KEGG
PC cid
PC sid
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histamine H2 receptor
(Cavia porcellus (domestic guinea pig))
Hoechst Pharmaceutical Research Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM22883
(CHEMBL12344 | Dimaprit | [3-(carbamimidoylsulfanyl...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 2.63E+4nM
Assay Description:
Compound is evaluated for histamine H2 receptor agonistic activity in guinea pig cerebral cortex using [3H]tiotidine as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
KEGG
PC cid
PC sid
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI