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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM92422(CHEMBL407391 | PU09)
Affinity DataKi:  1.43E+3nMAssay Description:Binding affinity to human GST tagged truncated LRRK2 G2019S mutant incubated for 2 hrs by TR-FRET based Lanthascreen kinase activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Sandia National Laboratories

Curated by ChEMBL
LigandPNGBDBM92422(CHEMBL407391 | PU09)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant ZAP70 using EEEEYEEEE as substrate by ESI-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Sandia National Laboratories

Curated by ChEMBL
LigandPNGBDBM92422(CHEMBL407391 | PU09)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant PYK2 by ESI-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase type 2-alpha(Homo sapiens (Human))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM92422(CHEMBL407391 | PU09)
Affinity DataKi:  1.50E+5nMAssay Description:Binding affinity (Ki) against human phosphatidylinositol 4-kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM92422(CHEMBL407391 | PU09)
Affinity DataIC50:  3.36E+3nMAssay Description:Inhibition of recombinant human GST tagged truncated LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate in presence of ATP preincuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University of Copenhagen

LigandPNGBDBM92422(CHEMBL407391 | PU09)
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:The screening of the compound library at the h5-HT3A-HEK293 cell line and the subsequent functional characterization of the compounds were performed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase type 2-alpha(Homo sapiens (Human))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM92422(CHEMBL407391 | PU09)
Affinity DataIC50:  2.18E+5nMAssay Description:Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM92422(CHEMBL407391 | PU09)
Affinity DataIC50:  1.50E+6nMAssay Description:Inhibition of HSP90 (unknown origin) by confocal fluorescence-based biochemical assayMore data for this Ligand-Target Pair