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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetHistamine H3 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263323(CHEMBL514217 | trans-3'-Oxo-3'H-spiro[cyclohexane-...)
Affinity DataIC50:  0.720nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263323(CHEMBL514217 | trans-3'-Oxo-3'H-spiro[cyclohexane-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of histamine H4 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263323(CHEMBL514217 | trans-3'-Oxo-3'H-spiro[cyclohexane-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of histamine H2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263323(CHEMBL514217 | trans-3'-Oxo-3'H-spiro[cyclohexane-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50263323(CHEMBL514217 | trans-3'-Oxo-3'H-spiro[cyclohexane-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed