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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM284000(E26 | US10023564, Example 26)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of GRK2 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM284000(E26 | US10023564, Example 26)
Affinity DataIC50:  1.20E+3nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM284000(E26 | US10023564, Example 26)
Affinity DataIC50:  4.00E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM284000(E26 | US10023564, Example 26)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of GRK5 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM284000(E26 | US10023564, Example 26)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM284000(E26 | US10023564, Example 26)
Affinity DataIC50: >1.00E+5nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent