Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetRenin(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL

LigandBDBM50011702(CHEMBL169870 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)Copy SMILESCopy InChI

Affinity DataIC50:  1.5nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using purified human kidney renin assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetRenin(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL

LigandBDBM50011702(CHEMBL169870 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)Copy SMILESCopy InChI

Affinity DataIC50:  2.5nMpH: 7.4Assay Description:In vitro renin inhibition was measured at pH 7.4 by using human plasma renin assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCathepsin E(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL

LigandBDBM50011702(CHEMBL169870 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)Copy SMILESCopy InChI

Affinity DataIC50:  165nMAssay Description:Inhibitory concentration against cathepsin EMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCathepsin D(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL

LigandBDBM50011702(CHEMBL169870 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)Copy SMILESCopy InChI

Affinity DataIC50:  250nMAssay Description:Inhibitory concentration against Cathepsin DMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGastricsin(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL

LigandBDBM50011702(CHEMBL169870 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)Copy SMILESCopy InChI

Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory concentration against GastricsinMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPepsin A(Porcine)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL

LigandBDBM50011702(CHEMBL169870 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy...)Copy SMILESCopy InChI

Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory concentration against PepsinMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI