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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Beta-secretase 1
(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center
Curated by
ChEMBL
Ligand
BDBM50580216
(MK-8931 | SCH 900931 | SCH-900931 | SCH900931 | VE...)
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Affinity Data
Ki: 0.400nM
Assay Description:
Displacement of [3H] JNJ-962 from BACE1 (unknown origin) expressed in HEK293 cell membranes assessed as inhibition constant at pH 6.2 by scintillatio...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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PC sid
PDB
In Depth
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Article
PubMed
PDB
3D Structure (crystal)
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Target
Beta-secretase 1
(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center
Curated by
ChEMBL
Ligand
BDBM50580216
(MK-8931 | SCH 900931 | SCH-900931 | SCH900931 | VE...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2nM
Assay Description:
Inhibition of BACE1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Beta-secretase 1
(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center
Curated by
ChEMBL
Ligand
BDBM50580216
(MK-8931 | SCH 900931 | SCH-900931 | SCH900931 | VE...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.20nM
Assay Description:
Inhibition of BACE-1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Beta-secretase 2
(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center
Curated by
ChEMBL
Ligand
BDBM50580216
(MK-8931 | SCH 900931 | SCH-900931 | SCH900931 | VE...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 11nM
Assay Description:
Displacement of [3H] JNJ-962 from BACE2 (unknown origin) expressed in HEK293 cell membranes assessed as inhibition constant at pH 6.2 by scintillatio...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Beta-secretase 1
(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center
Curated by
ChEMBL
Ligand
BDBM50580216
(MK-8931 | SCH 900931 | SCH-900931 | SCH900931 | VE...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4nM
Assay Description:
Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutation
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
PubMed
PDB
3D Structure (crystal)
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50580216
(MK-8931 | SCH 900931 | SCH-900931 | SCH900931 | VE...)
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Affinity Data
IC50: 2.20E+3nM
Assay Description:
Inhibition of human ERG expressed in HEK cells by voltage clamp assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
PubMed
Copy BDB DOI