Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329515((R)-2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-m...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329515((R)-2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-m...)
Affinity DataIC50:  2.48E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329515((R)-2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-m...)
Affinity DataIC50:  3.15E+3nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329515((R)-2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-m...)
Affinity DataEC50:  370nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed