Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL

LigandBDBM50303718(5-Adamantan-1-yl-2-amino-3-methyl-5-phenyl-3,5-dih...)Copy SMILESCopy InChI

Affinity DataIC50:  830nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL

LigandBDBM50303718(5-Adamantan-1-yl-2-amino-3-methyl-5-phenyl-3,5-dih...)Copy SMILESCopy InChI

Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL

LigandBDBM50303718(5-Adamantan-1-yl-2-amino-3-methyl-5-phenyl-3,5-dih...)Copy SMILESCopy InChI

Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL

LigandBDBM50303718(5-Adamantan-1-yl-2-amino-3-methyl-5-phenyl-3,5-dih...)Copy SMILESCopy InChI

Affinity DataIC50:  2.73E+4nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL

LigandBDBM50303718(5-Adamantan-1-yl-2-amino-3-methyl-5-phenyl-3,5-dih...)Copy SMILESCopy InChI

Affinity DataEC50:  930nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Merck

Curated by ChEMBL

LigandBDBM50543446(CHEMBL4634826)Copy SMILESCopy InChI

Affinity DataEC50:  12nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI