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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 17 hits in this display   

TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  770nMAssay Description:Inhibition of human BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  770nMAssay Description:Inhibition of human BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  770nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  3.44E+3nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  3.44E+3nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  3.44E+3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  3.48E+3nMAssay Description:Inhibition of human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using Rh-EVNLDAEFK-quencher as substrate measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of BACE1 mediated human Swedish amyloid precursor protein peptide hydrolysis by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of human recombinant renin by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of BACE1 mediated hydrolysis of human amyloid precursor protein with Swedish and London mutation in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataEC50:  4.17E+3nMAssay Description:Inhibition of human recombinant APP expressed in CHO-K1 cells assessed as reduction of amyloid beta level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed