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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Histone-lysine N-methyltransferase SMYD3
(Homo sapiens (Human))
Epizyme
US Patent
Ligand
BDBM378444
(N-((1R,3r,5S)-8-(((1-methylpiperidin-4-yl)methyl)s...)
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Affinity Data
IC50: 0.670nM
Assay Description:
The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Histone-lysine N-methyltransferase SMYD3
(Homo sapiens (Human))
Epizyme
US Patent
Ligand
BDBM378444
(N-((1R,3r,5S)-8-(((1-methylpiperidin-4-yl)methyl)s...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1nM
Assay Description:
Inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using N-terminal GST-tagged ...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone-lysine N-methyltransferase SMYD3
(Homo sapiens (Human))
Epizyme
US Patent
Ligand
BDBM378444
(N-((1R,3r,5S)-8-(((1-methylpiperidin-4-yl)methyl)s...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 480nM
Assay Description:
Inhibition of human SMYD3 expressed in HEK293T/17 cells using FLAG-tagged MEKK2 as substrate incubated for 30 mins in low air flow area followed by i...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI