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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Histone acetyltransferase KAT2B
(Homo sapiens (Human))
Genetech
US Patent
Ligand
BDBM50234944
(CHEMBL4072538 | US10239861, Example 60)
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Affinity Data
IC50: 235nM
Assay Description:
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
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PDB
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US Patent
PDB
3D Structure (crystal)
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Target
Histone acetyltransferase KAT2B
(Homo sapiens (Human))
Genetech
US Patent
Ligand
BDBM50234944
(CHEMBL4072538 | US10239861, Example 60)
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Affinity Data
IC50: 501nM
Assay Description:
Displacement of GSK3103956A from FLAG-6 His-Halo tagged human PCAF bromodomain (715 to 831 residues) incubated for 30 mins in dark by TR-FRET assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
PDB
Patents
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In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
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Target
Nucleosome-remodeling factor subunit BPTF
(Homo sapiens (Human))
University Of Minnesota
Curated by
ChEMBL
Ligand
BDBM50234944
(CHEMBL4072538 | US10239861, Example 60)
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Affinity Data
IC50: 1.90E+4nM
Assay Description:
Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assay
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Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
PDB
Patents
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In Depth
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Article
PubMed
PDB
3D Structure (crystal)
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Target
Bromodomain-containing protein 9
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50234944
(CHEMBL4072538 | US10239861, Example 60)
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Affinity Data
IC50: <5.01E+4nM
Assay Description:
Displacement of GSK2833930A from human BRD9 incubated for 30 mins in dark by TR-FRET assay
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI