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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
73
hits in this display
Target
Neuronal acetylcholine receptor subunit alpha-4
(Homo sapiens (Human))
University of Bath
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: 1.70nM
More data for this Ligand-Target Pair
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Target
Nicotinic acetylcholine receptor
(RAT)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: 3nM
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
TBA
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: 3nM
Assay Description:
Binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 by displacement of [3H](-)-cytisine from whole rat brain membranes
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
TBA
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: 4nM
Assay Description:
Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenates
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat))
Targacept
Curated by
PDSP K
i
Database
Ligand
BDBM50171341
(3-Methyl-5-(1-methyl-pyrrolidin-2-yl)-isoxazole | ...)
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Affinity Data
Ki: 4.69nM
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
TBA
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: 7.90nM
Assay Description:
Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha4-beta2
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
TBA
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 20nM
Assay Description:
Inhibition of [3H]-epibatidine binding to alpha 4 beta 2 nicotinic acetylcholine receptor of rat cortex membranes
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
TBA
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 20nM
Assay Description:
Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cortical membranes by beta counting
More data for this Ligand-Target Pair
Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat))
Targacept
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 20nM
Assay Description:
Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cortical membrane
More data for this Ligand-Target Pair
Target Info
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Target
Nicotinic acetylcholine receptor
(RAT)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035406
(3-Methyl-5-((R)-1-methyl-pyrrolidin-2-yl)-isoxazol...)
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Affinity Data
Ki: 44nM
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-5
(RAT)
Targacept
Curated by
PDSP K
i
Database
Ligand
BDBM50171341
(3-Methyl-5-(1-methyl-pyrrolidin-2-yl)-isoxazole | ...)
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Affinity Data
Ki: 803nM
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Università
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
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Affinity Data
Ki: 1.20E+3nM
Assay Description:
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in rat cortical membrane
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Università
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.20E+3nM
Assay Description:
Displacement of [125I]-alpha-Bungarotoxin from alpha7 nAChR rat cortical membranes by gamma counting
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Università
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.20E+3nM
Assay Description:
Inhibition of [125 I]-alpha Bungarotoxin binding to alpha 7 nicotinic acetylcholine receptor of rat cortex membranes
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Università
Curated by
ChEMBL
Ligand
BDBM50171341
(3-Methyl-5-(1-methyl-pyrrolidin-2-yl)-isoxazole | ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.97E+3nM
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.05E+3nM
Assay Description:
Bindind affinity value obtained by measuring the displacement of radioligand [125I]-alpha-bungarotoxin from K-28 cells stably express human Nicotinic...
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 1A/1B/1D/2C
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 2A
(PIG)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Adenosine receptor A1
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
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Target
Adenosine receptor A2a
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Adenylate cyclase type 9
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Solute carrier family 22 member 1
(RAT)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Adrenergic alpha2 receptor
(Mesocricetus auratus)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Beta-2 adrenergic receptor
(Mus musculus)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Type-2 angiotensin II receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Voltage-dependent N-type calcium channel subunit alpha-1B
(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Voltage-dependent T-type calcium channel subunit alpha-1H
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Chloride channel protein 1
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M1
(Mus musculus)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
NCI pathway
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Target
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Gamma-aminobutyric acid receptor subunit alpha-1
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Gamma-aminobutyric acid type B receptor subunit 1
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Glutamate receptor 3
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Ki: >1.00E+4nM
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Target
Glutamate receptor ionotropic, kainate 2
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
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Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Ki: >1.00E+4nM
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Target
Glutamate receptor ionotropic, NMDA 1
(RAT)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Ki: >1.00E+4nM
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Target
Glutamate receptor ionotropic, NMDA 1
(RAT)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Glutamate receptor ionotropic, NMDA 1
(RAT)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Ki: >1.00E+4nM
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Target
GLRA1 protein
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Ki: >1.00E+4nM
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Target
GLRA1 protein
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Ki: >1.00E+4nM
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Ki: >1.00E+4nM
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Target
Inositol-tetrakisphosphate 1-kinase
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Nicotinic acetylcholine receptor
(RAT)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035406
(3-Methyl-5-((R)-1-methyl-pyrrolidin-2-yl)-isoxazol...)
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Ki: >1.00E+4nM
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Target
Nicotinic acetylcholine receptor
(RAT)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035406
(3-Methyl-5-((R)-1-methyl-pyrrolidin-2-yl)-isoxazol...)
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Ki: >1.00E+4nM
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Target
Nicotinic acetylcholine receptor
(RAT)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Nicotinic acetylcholine receptor
(RAT)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Substance-P receptor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Substance-K receptor
(Bos taurus)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Ki: >1.00E+4nM
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Target
Beta-nerve growth factor
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Ki: >1.00E+4nM
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Target
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Ki: >1.00E+4nM
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Target
Apamin
(Apis mellifera (Honeybee))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Protein kinase C
(Drosophila melanogaster (Fruit fly))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Ki: >1.00E+4nM
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Target
Outer capsid protein sigma-1
(Mammalian orthoreovirus 3 Dearing)
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Ki: >1.00E+4nM
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Target
VIP peptides
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica)
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Affinity for Nicotinic acetylcholine receptor alpha4-beta2 in rat brain
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Università
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding potency for Nicotinic acetylcholine receptor alpha-7 (rat brain)
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Target
Neuronal acetylcholine receptor subunit alpha-3/beta-2
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
IC50: 62nM
Assay Description:
Inhibitory concentration required for in vitro binding affinity to Nicotinic acetylcholine receptor alpha3-beta2 expressed on cell line sf 9 by using...
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
IC50: 4.40E+4nM
Assay Description:
Inhibitory concentration required for in vitro binding affinity to cholinergic central muscarinic receptor on rat brain cortex by using [3H]OXO-M
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
IC50: 4.70E+4nM
Assay Description:
In vitro displacement of [3H]oxotremorine-M from muscarinic acetylcholine receptor in rat brain cortex
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Target
Acetylcholine receptor subunit delta
(Torpedo californica)
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
EC50: 4.11E+5nM
Assay Description:
Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype TE671 (muscle)
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Università
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
EC50: 2.64E+5nM
Assay Description:
Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype IMR-32 (ganglionic)
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Target
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica)
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
EC50: 4.11E+5nM
Assay Description:
Binding potency for Nicotinic acetylcholine receptor alpha4-beta2 (rat brain)
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Target
Neuronal acetylcholine receptor subunit alpha-3/beta-4
(Rattus norvegicus (Rat))
Swiss Federal Institute Of Technology Zurich
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
EC50: 2.09E+5nM
Assay Description:
Effective concentration against alpha3-beta4 Nicotinic acetylcholine receptor (nAChR)
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
EC50: 1.06E+4nM
Assay Description:
Tested for functional activity against neuronal nicotinic acetylcholine receptor(nAChR) expressed in K177 cells using isotopic rubidium efflux assay.
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Target
Acetylcholine receptor subunit alpha
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
EC50: 4.11E+5nM
Assay Description:
Tested for functional activity against alpha1 neuronal nicotinic acetylcholine receptor(nAChR) expressed in TE671 cells using isotopic rubidium efflu...
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
EC50: 2.64E+5nM
Assay Description:
Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha7
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
TBA
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
EC50: 6.00E+3nM
Assay Description:
Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor alpha4-beta2
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
TBA
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
EC50: 1.00E+4nM
Assay Description:
Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha4-beta2
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Target
Neuronal acetylcholine receptor subunit alpha-3/beta-4
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
EC50: 6.40E+4nM
Assay Description:
Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha4-beta2
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50035398
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
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Affinity Data
EC50: 1.06E+4nM
Assay Description:
Binding affinity against Nicotinic Acetylcholine Receptor was determined by measuring the displacement of [3H]-cytisine from a preparation of whole r...
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