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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50053631
(2-(4-Methyl-piperazin-1-yl)-quinoline | 2-(4-methy...)
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Affinity Data
Ki: 0.457nM
Assay Description:
Displacement of [3H]granisetron from 5HT3A receptor expressed in HEK293 cells after 24 hrs by scintillation counting in presence of quipazine
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Target
5-hydroxytryptamine receptor 3A/3B/3C/3D/3E
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50053631
(2-(4-Methyl-piperazin-1-yl)-quinoline | 2-(4-methy...)
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Affinity Data
Ki: 3nM
Assay Description:
Compound was tested for the inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universit£
Curated by
ChEMBL
Ligand
BDBM50053631
(2-(4-Methyl-piperazin-1-yl)-quinoline | 2-(4-methy...)
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Affinity Data
Ki: 3nM
Assay Description:
Ability to displace [3H]granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membrane
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universit£
Curated by
ChEMBL
Ligand
BDBM50053631
(2-(4-Methyl-piperazin-1-yl)-quinoline | 2-(4-methy...)
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Copy InChI
Affinity Data
Ki: 3nM
Assay Description:
Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor of rat cortical membrane
More data for this Ligand-Target Pair
Target Info
PDB
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GoogleScholar
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Novo Nordisk
Curated by
ChEMBL
Ligand
BDBM50053631
(2-(4-Methyl-piperazin-1-yl)-quinoline | 2-(4-methy...)
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Affinity Data
Ki: 410nM
Assay Description:
Antagonist potency against human H3 receptor in GTPgamma[S]-Assay
More data for this Ligand-Target Pair
Target Info
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antibodypedia
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by
ChEMBL
Ligand
BDBM50053631
(2-(4-Methyl-piperazin-1-yl)-quinoline | 2-(4-methy...)
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Affinity Data
Ki: 6.92E+3nM
Assay Description:
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI