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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 27 hits in this display   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  13nMAssay Description:Inhibition of DYRK1A (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  19nMAssay Description:Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  58nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  87nMAssay Description:Inhibition of TNIK (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  173nMAssay Description:Inhibition of MEK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  188nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Escherichia coli using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  212nMAssay Description:Inhibition of SGK (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  334nMAssay Description:Inhibition of MYLK (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  354nMAssay Description:Inhibition of FLT3 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  477nMAssay Description:Inhibition of TRKA (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  514nMAssay Description:Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1B(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  830nMAssay Description:Inhibition of CAMK1B (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))TBA
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  2.08E+3nMAssay Description:Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))TBA
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  6.71E+3nMAssay Description:Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  8.78E+3nMAssay Description:Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric s...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human DYRK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))TBA
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric ...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric sc...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))TBA
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50:  1.81E+4nMAssay Description:Inhibition of recombinant human CLK1 expressed in Sf9 insect cells using myelin basic protein as substrate incubated for 110 mins in presence of ATP ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataKd:  7.29E+3nMAssay Description:Binding affinity to human GSK-3beta assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataKd:  0.912nMAssay Description:Binding affinity to human DYRK1A assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataKd:  35nMAssay Description:Binding affinity to human CLK1 assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed