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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
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Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM355878
((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
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Affinity Data
IC50: 0.00400nM
Assay Description:
IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...
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Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824]
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM355878
((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
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Affinity Data
IC50: 0.00400nM
Assay Description:
The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...
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KEGG
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US Patent
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Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM355878
((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
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Affinity Data
IC50: 4nM
Assay Description:
Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg^Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...
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Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM355878
((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
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Copy InChI
Affinity Data
IC50: 40nM
Assay Description:
Inhibition of MALT1 in PMA-stimulated human Jurkat T cells assessed as reduction in IL2 level pretreated for 30 mins followed by PMA-stimulation meas...
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Article
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Target
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM355878
((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 800nM
Assay Description:
Inhibition of MALT1 in human whole blood assessed as reduction in PMA//anti-CD28 antibody-induced IL2 level pre-incubated for 1 hrs before stimulatio...
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM355878
((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP3A4 (unknown origin)
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM355878
((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP2C9 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Novartis Pharma
Curated by
ChEMBL
Ligand
BDBM355878
((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP2D6 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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