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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
25
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
Ki: 331nM
Assay Description:
Inhibition of human recombinant CA2 by stopped flow CO2 hydrase assay
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Target
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human))
Universit£
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ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
Ki: 341nM
Assay Description:
Inhibition of human recombinant CA5B by stopped flow CO2 hydrase assay
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
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ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
Ki: 353nM
Assay Description:
Inhibition of human recombinant CA9 by stopped flow CO2 hydrase assay
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
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ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
Ki: 362nM
Assay Description:
Inhibition of human recombinant CA1 by stopped flow CO2 hydrase assay
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Target
Carbonic anhydrase 3
(Homo sapiens (Human))
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ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
Ki: 374nM
Assay Description:
Inhibition of human recombinant CA3 by stopped flow CO2 hydrase assay
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Target
Carbonic anhydrase 6
(Homo sapiens (Human))
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ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
Ki: 412nM
Assay Description:
Inhibition of human recombinant CA6 by stopped flow CO2 hydrase assay
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Target
Carbonic anhydrase 15
(Mus musculus)
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BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
Ki: 461nM
Assay Description:
Inhibition of mouse recombinant CA15 by stopped flow CO2 hydrase assay
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Target
Carbonic anhydrase 14
(Homo sapiens (Human))
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ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
Ki: 473nM
Assay Description:
Inhibition of human recombinant CA14 by stopped flow CO2 hydrase assay
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Carbonic anhydrase 4
(Homo sapiens (Human))
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ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
Ki: 525nM
Assay Description:
Inhibition of human recombinant CA4 by stopped flow CO2 hydrase assay
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Carbonic anhydrase 13
(Homo sapiens (Human))
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ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
Ki: 1.21E+3nM
Assay Description:
Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay
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Target
Carbonic anhydrase 12
(Homo sapiens (Human))
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ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
Ki: 3.71E+3nM
Assay Description:
Inhibition of human recombinant CA12 by stopped flow CO2 hydrase assay
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Carbonic anhydrase 7
(Homo sapiens (Human))
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ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
Ki: 4.45E+3nM
Assay Description:
Inhibition of human recombinant CA7 by stopped flow CO2 hydrase assay
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Target
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human))
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ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
Ki: 4.57E+3nM
Assay Description:
Inhibition of human recombinant CA5A by stopped flow CO2 hydrase assay
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Target
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
IC50: 182nM
Assay Description:
Binding affinity to human inactivated voltage-gated Na channel 1.7 expressed in HEK293 cells by patch-clamp technique
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Target
Sodium channel protein type 3 subunit alpha
(Rattus norvegicus)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
IC50: 415nM
Assay Description:
Binding affinity to rat inactivated voltage-gated Na channel 1.3 expressed in human HEK293 cells by patch-clamp technique
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Target
Sodium channel protein type 10 subunit alpha
(Rattus norvegicus (Rat))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
IC50: 1.60E+4nM
Assay Description:
Binding affinity to voltage-gated Na channel 1.8 in Sprague-Dawley rat L4/L5 DRG neurons by patch-clamp technique
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
IC50: 5.01E+4nM
Assay Description:
Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...
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Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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Target
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Target
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
IC50: 1.82E+5nM
Assay Description:
Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin
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Target
Potassium voltage-gated channel subfamily E/KQT member 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
IC50: 2.51E+5nM
Assay Description:
Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...
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Target
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
IC50: 5.01E+5nM
Assay Description:
Inhibition of fast sodium current (INa) in Chinese Hamster Ovary (CHO) K1 cells transfected with human Nav1.5 measured using IonWorks Quattro automat...
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50300204
((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
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Affinity Data
IC50: 5.01E+7nM
Assay Description:
Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay
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