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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
2
hits in this display
Target
Beta-secretase 1
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM259257
(US9499502, Table A: Entry 89)
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Affinity Data
Ki: 1.90E+3nM ΔG°: -33.2kJ/mole
pH: 5.0 T: 2°C
Assay Description:
A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Beta-secretase 2
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM259257
(US9499502, Table A: Entry 89)
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Copy InChI
Affinity Data
Ki: 4.60E+3nM ΔG°: -31.0kJ/mole
pH: 5.0 T: 2°C
Assay Description:
Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI