Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 17 hits in this display   

TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant renin in presence of plasma by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant renin by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant renin by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50:  500nMAssay Description:Inhibition of alpha-adrenoceptor 1A (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of alpha-adrenoceptor 2B (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetMu-type opioid receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of mu opioid receptor (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of alpha-adrenoceptor 2A (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using 7-benzyl-4-trifluoromethylcoumarin as fluorometric substrateMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetCytochrome P450 2D6(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetBeta-secretase 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of BACE2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetCathepsin D(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetCathepsin E(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of cathepsin E (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetPepsin A-5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pepsin A (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGastricsin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pepsin C (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL

LigandBDBM50065660(CHEMBL3403995)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI