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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US11472795, Example C | US9611249,...)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged GSK3beta (1 to 420 end residues) expressed in baculovirus expression system using u...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US11472795, Example C | US9611249,...)
Affinity DataIC50:  20nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US11472795, Example C | US9611249,...)
Affinity DataIC50:  21.6nMAssay Description:The activity on human GSK-3β of the compounds of the invention listed in the following Table 1 and of the comparison compound C was assessed at ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US11472795, Example C | US9611249,...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in tail current by measuring tail current amplitude measured after deploarizat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US11472795, Example C | US9611249,...)
Affinity DataIC50:  49.9nMAssay Description:Confirmation of interaction with the potassium channels of the compounds of the invention listed in the following Table 1 and of the comparison compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US11472795, Example C | US9611249,...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human recombinant ERK5 by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US11472795, Example C | US9611249,...)
Affinity DataIC50:  530nMAssay Description:Inhibition of human recombinant GRK2 by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US11472795, Example C | US9611249,...)
Affinity DataIC50:  530nMAssay Description:Inhibition of human recombinant DYRK2 by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed