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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human))
Genuv
US Patent
Ligand
BDBM520650
(US11147816, Refametinib (RDEA119, Bay | US11701360...)
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Affinity Data
IC50: 19nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
US Patent
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human))
Genuv
US Patent
Ligand
BDBM520650
(US11147816, Refametinib (RDEA119, Bay | US11701360...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 19nM
Assay Description:
The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
US Patent
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Dual specificity mitogen-activated protein kinase kinase 2
(Homo sapiens (Human))
Genuv
US Patent
Ligand
BDBM520650
(US11147816, Refametinib (RDEA119, Bay | US11701360...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 47nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
US Patent
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Dual specificity mitogen-activated protein kinase kinase 2
(Homo sapiens (Human))
Genuv
US Patent
Ligand
BDBM520650
(US11147816, Refametinib (RDEA119, Bay | US11701360...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 47nM
Assay Description:
The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
US Patent
PDB
3D Structure (crystal)
Copy BDB DOI